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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Xanthomonas fuscans subsp. fuscans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:XFF6990_390257Imported
OrganismiXanthomonas fuscans subsp. fuscansImported
Taxonomic identifieri366649 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 175tRNA-synt_1InterPro annotationAdd BLAST157
Domaini225 – 421tRNA-synt_1_2InterPro annotationAdd BLAST197
Domaini436 – 590tRNA-synt_1InterPro annotationAdd BLAST155
Domaini637 – 675tRNA-synt_1InterPro annotationAdd BLAST39
Domaini718 – 841Anticodon_1InterPro annotationAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 56"HIGH" regionUniRule annotationAdd BLAST11
Motifi638 – 642"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2H1QWV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVEPNVYD PQQVETSAQQ FWDATRAFQV DENSEKPKFY CLSMLPYPSG
60 70 80 90 100
ALHMGHVRNY TISDVVSRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA
110 120 130 140 150
PAKWTYANIA HMRAQLKSLG YAIDWSREFA TCTPDYYVHE QRMFTRLMRK
160 170 180 190 200
GLAYRRNAVV NWDPIDQTVL ANEQVIDGRG WRSGAVVEKR EIPQWFLRIT
210 220 230 240 250
DYAQELLDGL DQLDGWPDSV KTMQRNWIGR SEGLEIQFDV RDTNGAALDP
260 270 280 290 300
LRVFTTRPDT LMGVTFVSIA AEHPLAVHAA KSNPELAALL ETLKHGGVSE
310 320 330 340 350
AELETQEKRG MATGLTAVHP ISGEQVPVWV ANFVLMGYGT GAVMAVPGHD
360 370 380 390 400
QRDFEFANKY GLPIVQVVKL REPRNEEEQT WDATHWRDWY TDKSRELELI
410 420 430 440 450
NSAEFDGLDF GGAFEALAER FERKGQGQRR VNYRLRDWGV SRQRYWGCPI
460 470 480 490 500
PVIYCAKCGA VPVPEDQLPV VLPENVEFSG TGSPIKTDPN WRQTTCPDCG
510 520 530 540 550
GPAERETDTF DTFMESSWYV ARYTSPKARD MVDRRANYWM PADLYVGGIE
560 570 580 590 600
HAILHLMYFR FYHKLMRDAR LVDSDEPVTN LLTQGMVIAD TFYRDADNGG
610 620 630 640 650
KDWINPADVE IQRDERGRVT GAVLIADGQP VQIGGTEKMS KSKNNGVDPQ
660 670 680 690 700
SMVAKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFMR RLWVQVHKHV
710 720 730 740 750
GEGAAAALDV AALNAEQKAI RRKTHETIGK VSDDYGRRHS FNTAIAAVME
760 770 780 790 800
LSNALAKFDD ISEQGRAVRQ EALEAMVLLL NPITPHASHA LWQVLGRGET
810 820 830 840 850
LLENVAFPQA DSSALVRDAL TLAVQINGKL RGTIDVAADA TREQIEALAQ
860 870 880
AEPNAAKFLE GLSVRKIIIV PGKIVNIVAG
Length:880
Mass (Da):98,505
Last modified:January 31, 2018 - v1
Checksum:iDB46C58A28887085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
OCYU01000033 Genomic DNA. Translation: SON96946.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2H1QWV8_9XANT
AccessioniPrimary (citable) accession number: A0A2H1QWV8
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: March 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)