Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate kinase

Gene

D915_02241

Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (D915_13480)
  2. Phosphoglycerate kinase (D915_03905), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase (D915_03906)
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. Pyruvate kinase (D915_02241), Pyruvate kinase (D915_13877)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
ORF Names:D915_02241Imported
OrganismiFasciola hepatica (Liver fluke)Imported
Taxonomic identifieri6192 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaEchinostomataEchinostomatoideaFasciolidaeFasciola

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 214PKInterPro annotationAdd BLAST203
Domaini231 – 341PK_CInterPro annotationAdd BLAST111

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Family and domain databases

Gene3Di2.40.33.101 hit
3.40.1380.201 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF51621 SSF51621, 1 hit
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2H1CRV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVVLFRRP AFLDCEVENG GKLGSRKGVN LPGAIVDLPA VSEKDKADLR
60 70 80 90 100
FAVEHNLDIV FASFIRNANA VLEIRDLLGK AGAHIKIIAK IENHEGVKRF
110 120 130 140 150
DEILEVVDGI MVARGDLGIE IPAEKVFVAQ KMMIGRCNQV GKPIICATQM
160 170 180 190 200
LESMTTKPRP TRAESSDVAN AVLDGADCVM LSGETAKGLY PLETVQTMHR
210 220 230 240 250
ICLQAEAAIF HGQLFEDLKA ALLGPVGMAH TTAVAAVEAA NRCNASAIIV
260 270 280 290 300
ITTSGGHRPR CPILAVTRHA VTARQANLFR GVHPLYYGEP RTQEWDEDVD
310 320 330 340 350
RRIHFAIEYG MKNSYLKPDS FVIIVTGWKA GSGSTNTLRV LRLEDAKSRP
360
IVATASSHRL NE
Length:362
Mass (Da):39,368
Last modified:January 31, 2018 - v1
Checksum:iB788FCC224778C35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KZ428585 Genomic DNA Translation: PIS90207.1

Similar proteinsi

Entry informationi

Entry nameiA0A2H1CRV9_FASHE
AccessioniPrimary (citable) accession number: A0A2H1CRV9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: March 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)