D915_03906

Functionⁱ

Catalytic activityⁱ

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (D915_13480)
Phosphoglycerate kinase (D915_03905), Phosphoglycerate kinase, Phosphoglycerate kinase (D915_03906), Phosphoglycerate kinase
no protein annotated in this organism
Enolase (ENO)
Pyruvate kinase (D915_13877), Pyruvate kinase (D915_02241)

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functionⁱ

phosphoglycerate kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycolytic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	KinaseUniRule annotationImported, Transferase

Molecular function

KinaseUniRule annotationImported, Transferase

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00185.

UniPathwayⁱ

UPA00109; UER00185.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesⁱ	ORF Names:D915_03906Imported
Organismⁱ	Fasciola hepatica (Liver fluke)Imported
Taxonomic identifierⁱ	6192 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Platyhelminthes › Trematoda › Digenea › Plagiorchiida › Echinostomata › Echinostomatoidea › Fasciolidae › Fasciola

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phosphoglycerate kinase family.UniRule annotation

Family and domain databases

Gene3Dⁱ	3.40.50.1260. 1 hit.
InterProⁱ	View protein in InterPro IPR001576. Phosphoglycerate_kinase. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A2H1CMG4-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MLDKVNELII TGGMAFTFLK KLHNMKIGKS LFDEPGAAIV DEVMALAKQK 
        60         70         80         90        100
KVEIHLPVDF VTGSKFGDDA TVGSATVESG IPDDYMGLDC GPKTMEKFRA 
       110        120        130        140        150
VILRAKTIVW NGPMGVFEME KFAGGTKAAM DAVVEATKNG ATTIIGGGDT 
       160        170        180        190 
ATCCAKWKTE DKVSHVSTGG GASLELLEGK ELPGVVALTN A

Length:191

Mass (Da):20,083

Last modified:January 31, 2018 - v1

Checksum:ⁱD1AFDBB3DC6502AB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KZ428915 Genomic DNA. Translation: PIS88655.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

KZ428915 Genomic DNA. Translation: PIS88655.1.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A2H1CMG4	C0L7L5	Fasciola hepatica (Liver fluke)	191	UniRef100_A0A2H1CMG4	Cluster: Phosphoglycerate kinase	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A2H1CMG4	Q45UT3 A0A183B9P9 C0L7L5	Fasciola hepatica (Liver fluke) Echinostoma caproni	437	UniRef90_Q45UT3	Cluster: Phosphoglycerate kinase	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A2H1CMG4	P09041 UPI000A30D06E Q5XIV1 UPI00042AAFAA UPI00022F521C UPI000A31AE53 UPI00038C3FF5 UPI0000029996 M5EBF1 A0A0B7KMH0 +584	Mus musculus (Mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Rattus norvegicus (Rat) Peromyscus maniculatus bairdii (Prairie deer mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mus caroli (Ryukyu mouse) (Ricefield mouse) Microtus ochrogaster (Prairie vole) Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated yeast) Bionectria ochroleuca (Gliocladium roseum) Capsaspora owczarzaki (strain ATCC 30864) And more	417	UniRef50_P09041	Cluster: Phosphoglycerate kinase 2	595

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KZ428915 Genomic DNA. Translation: PIS88655.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

KZ428915 Genomic DNA. Translation: PIS88655.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00185.

UniPathwayⁱ

UPA00109; UER00185.

Family and domain databases

Gene3Dⁱ	3.40.50.1260. 1 hit.
InterProⁱ	View protein in InterPro IPR001576. Phosphoglycerate_kinase. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A2H1CMG4_FASHE
Accessionⁱ	A0A2H1CMG4Primary (citable) accession number: A0A2H1CMG4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 31, 2018
	Last sequence update:	January 31, 2018
	Last modified:	March 28, 2018
	This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - A0A2H1CMG4 (A0A2H1CMG4_FASHE)

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Phosphoglycerate kinase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A2H1CMG4 (A0A2H1CMG4_FASHE)

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Phosphoglycerate kinase

D915_03906

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ