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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotationSAAS annotation
Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotationSAAS annotation

Cofactori

FADUniRule annotationSAAS annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA), Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei473Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 33FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFADUniRule annotationSAAS annotation, Flavoprotein, NADUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotationImported
ORF Names:AL530_022370Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000053643 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

SMRiA0A2G9BQR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PANTHERiPTHR11552:SF157 PTHR11552:SF157, 1 hit
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2G9BQR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDYIIIGA GSAGNVLATR LTEDPNTTVL LLEAGGPDYR FDFRTQMPAA
60 70 80 90 100
LAFPLQGKRY NWAYETEPEP FMNNRRMECG RGKGLGGSSL INGMCYIRGN
110 120 130 140 150
ALDLDNWAQE PSLENWSYLD CLPYYRKAET RDVGENDYHG GDGPVSVTTS
160 170 180 190 200
KPGVNPLFEA MIEAGMQAGY PRTDDLNGYQ QEGFGPMDRT VTPHGRRAST
210 220 230 240 250
ARGYLDQAKS RPNLTIRTHA MTDHIIFDGK RAVGVEWLEG DSTIPTRAAA
260 270 280 290 300
NKEVLLCAGA IASPQILQRS GVGNAELLAE FDIPLVHELP GVGENLQDHL
310 320 330 340 350
EMYLQYECKE PVSLYPALQW WNQPRIGAEW LFGGTGVGAS NHFEAGGFIR
360 370 380 390 400
SREEFAWPNI QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVRIK
410 420 430 440 450
SRDPHQHPGI LFNYMSHEQD WQEFRDAIRI TREIMHQPAL DQYRGREISP
460 470 480 490 500
GVECQTDEQL DEFVRNHAET AFHPCGTCKM GYDEMAVVDG EGRVHGLEGL
510 520 530 540 550
RVVDASIMPQ IITGNLNATT IMIGEKIADM IRGKEALPRS TAGYFVANGM

PVRAKK
Length:556
Mass (Da):61,899
Last modified:January 31, 2018 - v1
Checksum:i7958C0BD6D20BFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LORS02000001 Genomic DNA Translation: PNP65673.1
RefSeqiWP_001159142.1, NZ_PKHJ01000021.1

Similar proteinsi

Entry informationi

Entry nameiA0A2G9BQR6_ECOLX
AccessioniPrimary (citable) accession number: A0A2G9BQR6
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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