Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Proteobacteria bacterium
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase (CMK59_12060), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei164May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
ORF Names:CSB47_06270Imported
OrganismiProteobacteria bacteriumImported
Taxonomic identifieri1977087 [NCBI]
Taxonomic lineageiBacteriaProteobacteria
Proteomesi
  • UP000231221 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2G6D837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNACAQDT CNILPDIANE PHTGPNGLLN WVGMSEIEMP VKMITGNGDT
60 70 80 90 100
MQNVARVQAY VNLTDPESKG IHMSRLYLTV DQMLGNQVLT PQLLQNVVQQ
110 120 130 140 150
FVKTHDGISD NAYLECRFEF LERRSALISD NTGWKGYKVR AISSFKKGVM
160 170 180 190 200
TSELGIEVPY SSTCPCSAAL SRDLIQQGFR NQFGTEGMVS LKEVEQWLGT
210 220 230 240 250
KEGISATPHS QRSLAQVRVN LDERVNDLPI SRLIDSIEDA LQTPVQAAVK
260 270 280 290 300
REDEQEFARL NGQNLMFCED AARRLHDALD KDDTLQDFWV RVNHMESLHP
310 320
HDAVAIVVKG VENGYRDDPR EFPH
Length:324
Mass (Da):36,331
Last modified:January 31, 2018 - v1
Checksum:iE66CBF37F17DF4A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDPG01000043 Genomic DNA Translation: PID45909.1

Similar proteinsi

Entry informationi

Entry nameiA0A2G6D837_9PROT
AccessioniPrimary (citable) accession number: A0A2G6D837
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: April 25, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported