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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Gammaproteobacteria bacterium
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotationImported
ORF Names:CMQ17_00015Imported
OrganismiGammaproteobacteria bacteriumImported
Taxonomic identifieri1913989 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteria

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei732N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00613. GDC-P. 2 hits.
Gene3Di3.40.640.10. 2 hits.
3.90.1150.10. 1 hit.
HAMAPiMF_00711. GcvP. 1 hit.
InterProiView protein in InterPro
IPR003437. GcvP.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_dom1.
IPR015421. PyrdxlP-dep_Trfase_major.
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiView protein in Pfam
PF02347. GDC-P. 2 hits.
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2E8F4C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKSSSGAT VIPIHGESLP SLEKLQYTGE FIDRHIGPGE DQIQEMLKTL
60 70 80 90 100
GVKTLANLVK KTVPASIALK SPLQLNAPLT ESAALAKLQD TAAKNLPFRS
110 120 130 140 150
YIGLGYYDTH TPNVILRNVL ENPGWYTAYT PYQPEISQGR LECLLNFQQM
160 170 180 190 200
TLDLTAMELA NASLLDEATA AAEGMALAKR VSRNRKSNLF FVDQNCFPQT
210 220 230 240 250
IDVIRTRAEC FGIELIIGDV DTIRDHDLFG AIFQYPSMLG EAQDLTELIR
260 270 280 290 300
KLHEQKAIAI AAADLMSLVL LKPPGEMGAD VVTGSTQRFG VPMGYGGPHA
310 320 330 340 350
AYFATKDEFK RAVPGRIIGV SVDSRGKQAL RMALQTREQH IRREKANSNI
360 370 380 390 400
CTAQVLLANI SALYAMYHGA SGLKIIARRI HRLTTVLATG LERCGITIVN
410 420 430 440 450
DNYFDTLTLA VSKEQSIQII ANAQKAEVNL RLDRLRQHQQ ISLSLNECTS
460 470 480 490 500
TEDVVLLWQI LLGEQSNSLS VSAIDTAICE HQLPGAIPPS LQRQSGFLKH
510 520 530 540 550
PNFHNYRSET EMLRYLKRLE NKDISLNHSM IPLGSCTMKL NAVAEMMPIS
560 570 580 590 600
WPEFTKAHPF APMEQLRGYQ EMISELEQML AEITGFDAIS MQPNSGAQGE
610 620 630 640 650
YAGLLAIKKY LKNKGEGDRN ICLIPSSAHG TNPASAQMIG MDVVVIACDD
660 670 680 690 700
EGNIAVDDLS SKADKYSDKL AALMITYPST HGVYEESVRK ICKIIHAHGG
710 720 730 740 750
QVYMDGANLN AQVGVAKPAD IGADVSHVNL HKTFCIPHGG GGPGMGPIGV
760 770 780 790 800
KKHLAPFLAG HSMIELPGPK KSNGAVSAAP WGSAGILPIS WMYISMMGGE
810 820 830 840 850
GLLKATQVAI LNANYTAFKL APYYPVLYKG KNGLVAHECI IDLRPLKVSS
860 870 880 890 900
GISEEDVAKR LMDYGFHAPT MSFPVAGTLM IEPTESESKQ ELDRFITAMI
910 920 930 940 950
QIRSEIDQVE AGEIDAENNP LKNAPHTLTD ILDESWNRPY SKTQAAFPVS
960 970 980
GLSKNKYWPS VNRIDNVHGD RNLFCACPGF ESTQ
Length:984
Mass (Da):107,654
Last modified:January 31, 2018 - v1
Checksum:iB9348AFD1209CAB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PBTO01000001 Genomic DNA. Translation: MBQ12779.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2E8F4C9_9GAMM
AccessioniPrimary (citable) accession number: A0A2E8F4C9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: March 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported