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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Verrucomicrobiales bacterium
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei159May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
ORF Names:CMO62_04815Imported
OrganismiVerrucomicrobiales bacteriumImported
Taxonomic identifieri2026801 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobiales
Proteomesi
  • UP000228772 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2E7SES0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKHSSTSA VKTTLHDAQN TRDTRELPID KVGVRRLRFP IQVRDRAHVX
60 70 80 90 100
QNTIATVGXF VDXPMEFKGT HMSRFIEVLH SHGGMIHVEN IPDLLARMQE
110 120 130 140 150
RLKAXTSHLE MEXPYFITKK APATGREGXM DYNVRFEANA TGNDIDFVMT
160 170 180 190 200
LRVAVTTLCP CSKAISQFGA HNQRXEVTVA IRSSETVWXE DLITLVEQSA
210 220 230 240 250
SSELYSLLKR PDEKAVTERA YENPVXVEDL VRNVVLKLKA HEHVTWYRVE
260
AENFESIHNH NAYACIEKG
Length:269
Mass (Da):30,494
Last modified:January 31, 2018 - v1
Checksum:i280511E3BF806079
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PBQP01000083 Genomic DNA Translation: MBO57015.1

Similar proteinsi

Entry informationi

Entry nameiA0A2E7SES0_9BACT
AccessioniPrimary (citable) accession number: A0A2E7SES0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: April 25, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported