Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Verrucomicrobiales bacterium
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei164May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
ORF Names:CMO70_06610Imported
OrganismiVerrucomicrobiales bacteriumImported
Taxonomic identifieri2026801 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobiales

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiView protein in InterPro
IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERiPTHR36445. PTHR36445. 1 hit.
PfamiView protein in Pfam
PF02649. GCHY-1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2E3A2F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDGLHSPA IATSSVNIPL HDEQNTRDTR ELPIDKVGVR GLRFPIQVRD
60 70 80 90 100
RTRSAQNTIA TIGMFVDLPM EFKGTHMSRF VEVLNSHGQM IHVENIPDLL
110 120 130 140 150
CSMQQKLNAN TSHLEIDFPY FITKKAPITE HEGLMDYNIR FEANATGKEI
160 170 180 190 200
DFVMTLRIPV ATLCPCSKAI SNYGAHNQRG EVTIAIRSSE TVWIEELISL
210 220 230 240 250
VEESASCXLY SLXKRPXEKA VTERAXENPV FVEDLVRNIV LRLKXHKQIT
260 270
WYRVEAENFE XIHNHNAYAC IEKAKKQID
Length:279
Mass (Da):31,769
Last modified:January 31, 2018 - v1
Checksum:i13DEE68731BCB103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PAOJ01000054 Genomic DNA. Translation: MBA19377.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2E3A2F1_9BACT
AccessioniPrimary (citable) accession number: A0A2E3A2F1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: March 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported