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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

CMM18_02750

Organism
Rhodospirillaceae bacterium
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
LigandPyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:CMM18_02750Imported
OrganismiRhodospirillaceae bacteriumImported
Taxonomic identifieri1898112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceae

Subcellular locationi

GO - Cellular componenti

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini144 – 181Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom_sf.
IPR036625. E3-bd_dom_sf.
IPR006257. LAT1.
IPR004167. PSBD.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
PS51826. PSBD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2E0GGN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPISVKMPAL SPTMEEGSLT KWLVKEGDNV VAGDIIAEVE TDKATMEVEA
60 70 80 90 100
VEDGVFSKII VPEGTNSVPV NKVIALMLEE GEDKSSLDNL ETIDDSSQED
110 120 130 140 150
TAIDKAVIEN KKEIISEEKT EIPIESSLVT DNVINIENDL KRVIASPLAK
160 170 180 190 200
RMALQANLDI SKVSGTGPRG RVIKNDILSF LGNPKVSEKN LNEEFLSKNS
210 220 230 240 250
SENFVKIPNS NMRKIIAERL SQSKQEIPHF YLTVDCEIDE LLSLRKDLNS
260 270 280 290 300
RSKDGRFKLS INDFVISAVA QALSKVPETN SSWSKESIIQ YKNIDISIAV
310 320 330 340 350
ALDEGLITPV IRDANQKGLA EISNEMKDLV DKANNNKLMP EDYKGGTFSI
360 370 380 390 400
SNLGMYGIKE FAAVINPPQG AILAVGKGEE RAIVKDGALS IANIMTCTLS
410 420 430
CDHRVVDGAV GSKFLTQFKE FIEDPVSMML
Length:430
Mass (Da):47,077
Last modified:January 31, 2018 - v1
Checksum:iFACCA4E046116E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NZXH01000024 Genomic DNA. Translation: MAR79133.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2E0GGN0_9PROT
AccessioniPrimary (citable) accession number: A0A2E0GGN0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: March 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported