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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Cyanobium sp. MED195
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotationSAAS annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation
LigandNADPUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
ORF Names:CL860_03110Imported
OrganismiCyanobium sp. MED195Imported
Taxonomic identifieri2024870 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeCyanobium

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 289AldedhInterPro annotationAdd BLAST274

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd07079. ALDH_F18-19_ProA-GPR. 1 hit.
Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
IPR000965. GPR_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiView protein in PROSITE
PS01223. PROA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2D7U575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQGVPEPS ADLLRLATAV RRAAVGXGQS SNQQRQQALM AMAASLEAHX
60 70 80 90 100
DRXVAANAED LAQASADGLA PALVXRLKLD AGKLAGAIXG VRQLSSLXDP
110 120 130 140 150
XGARQLHREL ADGLVLERVT VPLGVLGVIF EARPDAVIQI AALAIRSGNG
160 170 180 190 200
AILKGGSEAK CTNQAVMQSL KEGLAGTSVS ADALDLLTTR AESLALLRLD
210 220 230 240 250
GLVDLIIPRG SNELVRFIQD NTRIPVLGHA DGVCHLXVDQ EVDCAQALRI
260 270 280 290 300
AIDSKTQYPA ACNAIETLLV HEQIAPIFLK EAVPAFQAAG VCLRGDEASR
310 320 330 340 350
DLGVEQVATS DDWSQEYLDL VLAVRVVKDL DEALEHIRTY GSRHTEAIAT
360 370 380 390 400
VNHDTAERFL RAVDSSGVXH NCSTRFADGF RYGFGAEVGI STQTLPPRGP
410 420 430 440
VGLEGLVTYR YRLRGEGHVA ADFAEGRTQF SHRDLPLGTE
Length:440
Mass (Da):46,849
Last modified:January 31, 2018 - v1
Checksum:iE8C4229AC1C98567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NZJI01000036 Genomic DNA. Translation: MAK15643.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2D7U575_9CYAN
AccessioniPrimary (citable) accession number: A0A2D7U575
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: March 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported