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Protein

Gag polyprotein

Gene

gag

Organism
Human immunodeficiency virus 2
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinUniRule annotation
Biological processHost-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Viral release from host cell
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotationSAAS annotation
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 2Imported
Taxonomic identifieri11709 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host cytoplasm UniRule annotationSAAS annotation
  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini390 – 405CCHC-typeInterPro annotationAdd BLAST16
Domaini412 – 427CCHC-typeInterPro annotationAdd BLAST16

Sequence similaritiesi

Belongs to the primate lentivirus group gag polyprotein family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30, 1 hit
1.10.150.90, 1 hit
1.10.375.10, 1 hit
InterProiView protein in InterPro
IPR000721 Gag_p24
IPR000071 Lentvrl_matrix_N
IPR012344 Matrix_HIV/RSV_N
IPR008916 Retrov_capsid_C
IPR008919 Retrov_capsid_N
IPR010999 Retrovr_matrix
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00540 Gag_p17, 1 hit
PF00607 Gag_p24, 1 hit
PF00098 zf-CCHC, 2 hits
PRINTSiPR00234 HIV1MATRIX
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF47836 SSF47836, 1 hit
SSF47943 SSF47943, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 2 hits

Sequencei

Sequence statusi: Complete.

A0A2D3HX05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARSSVLRG KKADELEKIR LRPGGKKKYR LKHIVWAANE LDRFGLAESL
60 70 80 90 100
LESKEGCHKI LAVLDPLVPT GSENLKSLFN TVCVIWCLHA EEKVKDTEGA
110 120 130 140 150
KQIVQRHLAA ETGTADKMPS TSRPTAPPSG KGGNYPVQQV AGNYTHIPLS
160 170 180 190 200
PRTLNAWVKL VEEKKFGAEV VPGFQALSEG CTPYDINQML NCVGDHQGAM
210 220 230 240 250
QIVREIINEE AADWDTAHPI PGPLPAGQLR EPRGSDIAGT TSTVEEQIQW
260 270 280 290 300
MYRAQNPIPV GNIYRRWIQI GLQKCVRMYC ATNILDIKQG PKESFQSYVD
310 320 330 340 350
RFYKSLRAEQ TDPAVKNWMT QTLLVQNANP DCKLVLKGLG MNPTLEEMLI
360 370 380 390 400
ACQGVGGPGQ KARLMAEALK EAMTPAPIPF AAAQQKKAIR CWNCGKEGHS
410 420 430 440 450
ARQCRAPRRQ GCWKCGKQGH IMTNCPDRQA GFLGIGPWGK KPRNFPVAQI
460 470 480 490 500
PQGLTPTAPP MDPAVDLLEK YMQQGRKQRE QRQRPYKEVT EDLLHLGQGE
510 520
TPHREETDDL LHLNSLFGKD Q
Length:521
Mass (Da):57,925
Last modified:January 31, 2018 - v1
Checksum:i495FB0370473E2DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MF595866 Genomic DNA Translation: ATU79283.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Similar proteinsi

Entry informationi

Entry nameiA0A2D3HX05_9HIV2
AccessioniPrimary (citable) accession number: A0A2D3HX05
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: April 25, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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