Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Kazachstania unispora
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotationSAAS annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiKazachstania unisporaImported
Taxonomic identifieri27294 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei56 – 80HelicalSequence analysisAdd BLAST25
Transmembranei101 – 119HelicalSequence analysisAdd BLAST19
Transmembranei149 – 172HelicalSequence analysisAdd BLAST24
Transmembranei184 – 212HelicalSequence analysisAdd BLAST29
Transmembranei244 – 262HelicalSequence analysisAdd BLAST19
Transmembranei274 – 291HelicalSequence analysisAdd BLAST18
Transmembranei303 – 326HelicalSequence analysisAdd BLAST24
Transmembranei338 – 359HelicalSequence analysisAdd BLAST22
Transmembranei371 – 394HelicalSequence analysisAdd BLAST24
Transmembranei414 – 432HelicalSequence analysisAdd BLAST19
Transmembranei452 – 473HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 542COX1InterPro annotationAdd BLAST542

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2D0W3S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRWLYSTN AKDISIMYFM LALFSGMAGS AMSMIIRMEL AAPGSQYLHG
60 70 80 90 100
NNQLFNVLVV GHAVLMIFFL AMPALIGGFG NYMLPLMIGA TDMSFPRINS
110 120 130 140 150
IGFWLLPMGL VCLVTSTLVE SGAGTGWTVY PPLASIQAHS GPSVDLAIFS
160 170 180 190 200
LHLTSISSLL GAINFIVTTL NMRTNGMSMH KMPLFVWAIF ITAFLLLLSL
210 220 230 240 250
PVLSAGITML LMDRNFNTSF FEVAGGGDPI FYQHAFWFFG HPEVYILIIP
260 270 280 290 300
GFGIISHIVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD
310 320 330 340 350
TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLAVPMMF AIAFLFLFTI
360 370 380 390 400
GGLTGVVLAN ASLDVAFHDT YYVVGHFHYV LSMGAIFSLF AGYYYWSPQM
410 420 430 440 450
LGLDYNEKLA QIQFWLIFIG ANVVFLPMHF LGINGMPRRI PDYPDAFAGW
460 470 480 490 500
NYVSSVGSLI AMVSLFLFVY IMYDQIMNGV TNPGPAGSKA SGWNTHKLIY
510 520 530 540
KTPDFMESNR IFKLNVVKSS SIEFLLNSPP AVHAFNTPAV QS
Length:542
Mass (Da):59,731
Last modified:January 31, 2018 - v1
Checksum:i418F100266BDFD8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU920680 Genomic DNA Translation: APD15112.1

Similar proteinsi

Entry informationi

Entry nameiA0A2D0W3S1_9SACH
AccessioniPrimary (citable) accession number: A0A2D0W3S1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 31, 2018
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health