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Protein
Submitted name:

ephrin type-A receptor 3 isoform X3

Gene

epha3

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATPUniRule annotation1
Active sitei746Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi627 – 635ATPUniRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ephrin type-A receptor 3 isoform X3Imported
Gene namesi
Name:epha3Imported
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)Imported
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
Proteomesi
  • UP000221080 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei542 – 564HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501303950020 – 956Sequence analysisAdd BLAST937

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 207Eph LBDInterPro annotationAdd BLAST179
Domaini325 – 435Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini436 – 531Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini621 – 882Protein kinaseInterPro annotationAdd BLAST262

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd10481. EphR_LBD_A3. 1 hit.
cd00063. FN3. 2 hits.
Gene3Di2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR027936. Eph_TM.
IPR034266. EphA3_rcpt_lig-bd.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR008979. Galactose-bd-like_sf.
IPR009030. Growth_fac_rcpt_cys_sf.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
PfamiView protein in Pfam
PF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2D0R5Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCTRFLTLL LLLFMLVSCA EFIVYPSNEV NLLDSKASQG ELGWISYPPH
60 70 80 90 100
GWEEISGVDE HYTPIRTFQV CNVMEYSQNN WLRTNWIPRS SAQKIYVELK
110 120 130 140 150
FTLRDCNSIP LVLGTCKETF NLHYLETDED QGSKFREHQF SKIDTIAADE
160 170 180 190 200
SFTQMDLGDR ILKLNTEVRE VGPVTKKGFY LAFQDVGACV ALVSVRVYFK
210 220 230 240 250
KCPFTVRNLA SFPDTVPMDT QSLVEVRGSC VNNSKEEDPP KMYCSTEGEW
260 270 280 290 300
LVPIGKCLCN IGYEDRGVTC QACRPGFYKA SSGNMKCSKC PPHSYTHKEG
310 320 330 340 350
AVHCICDKNY FRADGDPVSM ACTRPPSAPR NVISVINETS VILDWSWPED
360 370 380 390 400
TGGRKDLIFK VVCKRCLAGS KQCEPCRGAV RFLPRASGLL NTTVTVADLL
410 420 430 440 450
AHTNYTFEIE AENGVSSLAP AMRQHASVTI TTNQAAPSQV TIIRKDRTSR
460 470 480 490 500
NSISLSWLEP ERPNGIILDY EVKYYEKQEQ ETSYTILRCK GTNVTLNGLK
510 520 530 540 550
PDTRYLLQIR ARTAAGYGSS SRKFEFETSP DSFSISSENS QVVLIAIASA
560 570 580 590 600
VAIILLTVVL YIVISRCCGY SKSKHPDKKR LHFGNGHLRL PGIRTYVDPH
610 620 630 640 650
TYEDPSQAVH EFAKELDASC IAIDKVVGAG EFGEVCSGRL KLPSKKEICV
660 670 680 690 700
AIKTLKAGYT ETQRRDFLSE ASIMGQFDHP NIIRLEGVVT RSKPVMIVTE
710 720 730 740 750
YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM GYVHRDLAAR
760 770 780 790 800
NILVNSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK
810 820 830 840 850
FTSASDVWSY GIVLWEVLSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP
860 870 880 890 900
APLYQLMLDC WQKDRNNRPK FEQIVSILDK LIRNPGSLKI TASTASRPVN
910 920 930 940 950
QLQTSTDITS FSTVGHWLES ARTLPCKEAF SGVSYSSCDT LPKTSADFPE

PSNPIA
Length:956
Mass (Da):106,897
Last modified:December 20, 2017 - v1
Checksum:i18543095E90B9D30
GO

Sequence databases

RefSeqiXP_017325937.1. XM_017470448.1.
UniGeneiIpu.29825.

Genome annotation databases

GeneIDi108266754.

Similar proteinsi

Entry informationi

Entry nameiA0A2D0R5Q1_ICTPU
AccessioniPrimary (citable) accession number: A0A2D0R5Q1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported