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Protein
Submitted name:

neurotrypsin isoform X1

Gene

prss12

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
neurotrypsin isoform X1Imported
Gene namesi
Name:prss12Imported
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)Imported
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
Proteomesi
  • UP000221080 Componenti: Genome assembly

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501209037529 – 822Sequence analysisAdd BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi140 ↔ 204PROSITE-ProRule annotation
Disulfide bondi153 ↔ 214PROSITE-ProRule annotation
Disulfide bondi184 ↔ 194PROSITE-ProRule annotation
Disulfide bondi250 ↔ 314PROSITE-ProRule annotation
Disulfide bondi263 ↔ 324PROSITE-ProRule annotation
Disulfide bondi294 ↔ 304PROSITE-ProRule annotation
Disulfide bondi400 ↔ 410PROSITE-ProRule annotation
Disulfide bondi470 ↔ 534PROSITE-ProRule annotation
Disulfide bondi483 ↔ 544PROSITE-ProRule annotation
Disulfide bondi514 ↔ 524PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 113KringleInterPro annotationAdd BLAST74
Domaini115 – 215SRCRInterPro annotationAdd BLAST101
Domaini225 – 325SRCRInterPro annotationAdd BLAST101
Domaini332 – 431SRCRInterPro annotationAdd BLAST100
Domaini445 – 545SRCRInterPro annotationAdd BLAST101
Domaini576 – 821Peptidase S1InterPro annotationAdd BLAST246

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

KOiK09624

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 1 hit
3.10.250.10, 4 hits
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
PF00530 SRCR, 4 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
PR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00130 KR, 1 hit
SM00202 SR, 4 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 4 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS00420 SRCR_1, 3 hits
PS50287 SRCR_2, 4 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2D0QFT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASARSCSS ACLPLFFLLL LCVSRTSAFL NPFSECTQSR GRGASYRGSV
60 70 80 90 100
DVTESGARCM NWTDVSGVTA RYPGKGLGEH NFCRNPDARI RPWCFFRNAR
110 120 130 140 150
GRIDWGYCDC KQGSVRLQGG RSKLDGTVEV YMNGAWGTIC SNDWDDRDAH
160 170 180 190 200
VVCQQLGQGY KARARASSLS RLPLAVVHWR TIGCSGDEAD LLQCPRSVWN
210 220 230 240 250
GGECANRQAA AVTCTPVEAA SFVPVRLSGG ATVYEGRVEV YHAGQWGTVC
260 270 280 290 300
DDQWDNNDAE VVCRQLGLGG TAKAWVGAYF GAGVGRVLLD EVSCTGNELS
310 320 330 340 350
IEQCPKTAWG EHNCDHTEDA GVSCTPLTDG SVRLVGGAGG FEGRLEVHYQ
360 370 380 390 400
GRWGTVCDDG WTSTNTQVVC RQLGYRSGQS VNPERFGTPP GPILLDDVSC
410 420 430 440 450
TGKEPALAHC AKREWLRHDC KHTEDVAVVC STQRTGHGVP TSVPVRLVGG
460 470 480 490 500
ENEREGRVEI LVSGQWGTIC DDGWTDEDAE VVCRQLGYSG AAKARVMAYF
510 520 530 540 550
GEGHGPIHVD NVKCTGAERS LADCIKQPIG SHDCRHSEDA GVICNYGQRD
560 570 580 590 600
NSTRVKADVA SSVCGLRPTH TRRKRIIGGQ NSLRGGWPWQ VAVRLRGSPS
610 620 630 640 650
DGRLVCGATL ISSCWVLTSA HCFKRYGNST STYKVRVGDY HTLVPEEHED
660 670 680 690 700
EYGVDRLVLH PRYRPQSNDY DLALARLTQH GGHSGECVRQ NHAVLPACLP
710 720 730 740 750
EWREKAPKDL TKCYITGWGD TGRAYSKTLQ QAAITVLGKR HCERHYGNRL
760 770 780 790 800
TSRMLCAGSA LSGHHVDSCR GDSGGPLVCE RGGSWTVYGV TSWGHACRLQ
810 820
DSPGVYTKVS AFMPWITKVT SQ
Length:822
Mass (Da):89,513
Last modified:December 20, 2017 - v1
Checksum:iC16D0A25DB844E93
GO

Sequence databases

RefSeqiXP_017317167.1, XM_017461678.1
UniGeneiIpu.61319

Genome annotation databases

GeneIDi108260944
KEGGiipu:108260944

Similar proteinsi

Entry informationi

Entry nameiA0A2D0QFT7_ICTPU
AccessioniPrimary (citable) accession number: A0A2D0QFT7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: April 25, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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