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Protein

Phosphoenolpyruvate carboxykinase (ATP)

Gene

pckA

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotationSAAS annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Metal bindingi201ManganeseUniRule annotation1
Binding sitei201ATPUniRule annotation1
Binding sitei201SubstrateUniRule annotation1
Metal bindingi220Manganese; via tele nitrogenUniRule annotation1
Binding sitei220ATPUniRule annotation1
Metal bindingi257ManganeseUniRule annotation1
Binding sitei285ATPUniRule annotation1
Binding sitei321ATPUniRule annotation1
Binding sitei321SubstrateUniRule annotation1
Binding sitei446ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi236 – 244ATPUniRule annotation9
Nucleotide bindingi440 – 441ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, KinaseImported, Lyase, Transferase
Biological processGluconeogenesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase (ATP)UniRule annotationSAAS annotation (EC:4.1.1.49UniRule annotationSAAS annotation)
Short name:
PCKUniRule annotation
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckAUniRule annotation
ORF Names:APX02_01290Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili498 – 518Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd00484. PEPCK_ATP. 1 hit.
Gene3Di3.40.449.10. 2 hits.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiView protein in InterPro
IPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
PANTHERiPTHR30031. PTHR30031. 1 hit.
PfamiView protein in Pfam
PF01293. PEPCK_ATP. 1 hit.
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiView protein in PROSITE
PS00532. PEPCK_ATP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2A3KKH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDTYTETT KIDKLLKKPT SHFQLSTTQL YNKILDNNEG VLTELGAVNA
60 70 80 90 100
STGKYTGRSP KDKFFVSEPS YRDNIDWGEI NQPIDEETFL KLYHKVLDYL
110 120 130 140 150
DKKDELYVFK GYAGSDKDTM LKLTVINELA WHNLFAKNMF IRPESKEEAT
160 170 180 190 200
KIKPNFTIVS APHFKADPEV DGTKSETFVI ISFKHKVILI GGTEYAGEMK
210 220 230 240 250
KGIFSVMNYL LPMQDIMSMH CSANVGEKGD VALFFGLSGT GKTTLSADPH
260 270 280 290 300
RKLIGDDEHG WNKNGVFNIE GGCYAKAINL SKEKEPQIFD AIKYGAILEN
310 320 330 340 350
TVVSEDGSVD FEDNRYTENT RAAYPINHID NIVVPSKAAH PNTIIFLTAD
360 370 380 390 400
AFGVIPPISK LNKDQAMYHF LSGFTSKLAG TERGVTEPEP SFSTCFGAPF
410 420 430 440 450
FPLHPTVYAD LLGELIDLHD VDVYLVNTGW TGGKYGVGRR ISLHYTRQMV
460 470 480 490 500
NQAISGKLKN AKYTKDSTFG LSIPVEIEDV PKTILNPINA WSDKEKYKAQ
510 520 530
AEDLIQRFEK NFEKFGEKVE HIAEKGSFNK
Length:530
Mass (Da):59,392
Last modified:December 20, 2017 - v1
Checksum:i564FE879214D60E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LKYR01000010 Genomic DNA. Translation: PBI77516.1.
RefSeqiWP_000109913.1. NZ_NXFU01000002.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2A3KKH0_STAAU
AccessioniPrimary (citable) accession number: A0A2A3KKH0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported