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Protein

Peptide deformylase

Gene

def

Organism
Rhodococcus sp. ACPA1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotationSAAS annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103IronUniRule annotation1
Metal bindingi145IronUniRule annotation1
Active sitei146UniRule annotation1
Metal bindingi149IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotationSAAS annotation (EC:3.5.1.88UniRule annotationSAAS annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
ORF Names:CJ177_16365Imported
OrganismiRhodococcus sp. ACPA1Imported
Taxonomic identifieri2028572 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000217882 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00487. Pep_deformylase. 1 hit.
Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase. 1 hit.
InterProiView protein in InterPro
IPR023635. Peptide_deformylase.
IPR036821. Peptide_deformylase_sf.
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiView protein in Pfam
PF01327. Pep_deformylase. 1 hit.
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2A3GNG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILPIRIVG DPVLHEPTEA VSQSPAELAE IIADMYDTMD AANGVGLAAN
60 70 80 90 100
QVGLPLRLFV YDCPDVDGNG TALRRRGCVV NPVLETSERP ETMPDPDDDV
110 120 130 140 150
EGCLSVPGEQ FPTGRAEWAK VTGTDADGNA VEIEGHGFFA RMLQHEVGHL
160 170 180 190
DGFLYVDMLV GRNARAAKKT IKRAGWGVPG LSWVPGTVED PFGHDD
Length:196
Mass (Da):21,020
Last modified:December 20, 2017 - v1
Checksum:i15C3FDFB5F9EE3E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NSDX01000003 Genomic DNA. Translation: PBC57132.1.
RefSeqiWP_005251736.1. NZ_NSDX01000003.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2A3GNG6_9NOCA
AccessioniPrimary (citable) accession number: A0A2A3GNG6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported