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Protein

Quinolinate synthase A

Gene

nadA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotationSAAS annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA), Quinolinate synthase (BGL62_06235), Quinolinate synthase (AC783_03365), Quinolinate synthase (BGL73_04555), Quinolinate synthase (HPMKF3_0043), Quinolinate synthase (BGL58_03270), Quinolinate synthase (BB390_03560), Quinolinate synthase (AA971_06325), Quinolinate synthase (BGL85_03255), Quinolinate synthase (BB463_00520), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB425_05080), Quinolinate synthase (BB399_06925), Quinolinate synthase (AA977_07105), Quinolinate synthase (BB392_04940), Quinolinate synthase (BB458_04130), Quinolinate synthase (AEY53_04695), Quinolinate synthase (AC786_05590), Quinolinate synthase (CEP78_008860), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (HPF94_0043), Quinolinate synthase (BB403_04690), Quinolinate synthase (HPF55_0045), Quinolinate synthase (BB428_03850), Quinolinate synthase (BGL71_06650), Quinolinate synthase (AK968_04145), Quinolinate synthase (AEY55_07010), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (AM496_03720), Quinolinate synthase A (nadA), Quinolinate synthase (BZK19_04595), Quinolinate synthase (HPF210_0043), Quinolinate synthase A (nadA), Quinolinate synthase (AA974_06160), Quinolinate synthase A (nadA), Quinolinate synthase (BB395_04085), Quinolinate synthase (BB445_06880), Quinolinate synthase (HPF38_0050), Quinolinate synthase (BGL77_00455), Quinolinate synthase (HPF17_0045), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB401_04235), Quinolinate synthase (BB464_04980), Quinolinate synthase (BB388_00285), Quinolinate synthase (BGL83_04195), Quinolinate synthase (HPF51_0044), Quinolinate synthase (HPF20_0047), Quinolinate synthase (ACM24_00465), Quinolinate synthase (BB475_02850), Quinolinate synthase (BB430_03035), Quinolinate synthase (BB394_06350), Quinolinate synthase (HPMKM6_0049), Quinolinate synthase (HPF78_0049), Quinolinate synthase (BB397_07615), Quinolinate synthase (BB386_06910), Quinolinate synthase A (nadA), Quinolinate synthase (BB449_05335), Quinolinate synthase A (nadA), Quinolinate synthase (ACM25_04670), Quinolinate synthase (AA973_06160), Quinolinate synthase A (nadA), Quinolinate synthase (BGL55_07905), Quinolinate synthase (BGL67_05465), Quinolinate synthase (BGL81_03250), Quinolinate synthase (AC782_02175), Quinolinate synthase (ACM29_05840), Quinolinate synthase (BB431_05820), Quinolinate synthase (BZK20_00770), Quinolinate synthase A (nadA), Quinolinate synthase (BZK21_01005), Quinolinate synthase (ACM26_07720), Quinolinate synthase A (nadA), Quinolinate synthase (BB482_06490), Quinolinate synthase (AEY52_07200), Quinolinate synthase (HPY499_01385), Quinolinate synthase (BB461_05325), Quinolinate synthase (BZK27_01705), Quinolinate synthase (AA976_06880), Quinolinate synthase A (nadA), Quinolinate synthase (BB483_07670), Quinolinate synthase (HPF209_0046), Quinolinate synthase (ACM32_02395), Quinolinate synthase (ACM37_05900), Quinolinate synthase (HPMKM1_0044), Quinolinate synthase (AB991_05550), Quinolinate synthase A (nadA), Quinolinate synthase (HPY228_06205), Quinolinate synthase (HPMKF10_0090), Quinolinate synthase (BIZ48_04360), Quinolinate synthase (BB423_05755), Quinolinate synthase (AB891_06965), Quinolinate synthase (BB409_06655), Quinolinate synthase A (nadA), Quinolinate synthase (ACM28_02565), Quinolinate synthase (BGL76_00185), Quinolinate synthase A (nadA), Quinolinate synthase (EE66_07745), Quinolinate synthase (ACM31_06075), Quinolinate synthase A (nadA), Quinolinate synthase (BB448_06675), Quinolinate synthase (BGL60_02890), Quinolinate synthase (JM68_01315), Quinolinate synthase A (nadA), Quinolinate synthase (BB447_01570), Quinolinate synthase (BGL74_00845), Quinolinate synthase (BB389_07500), Quinolinate synthase (AC784_04740), Quinolinate synthase (HPY1846_02420), Quinolinate synthase (BB434_03360), Quinolinate synthase (BZK26_07335), Quinolinate synthase (BGL64_00830), Quinolinate synthase (BB436_03185), Quinolinate synthase (BGL59_02580), Quinolinate synthase (BB471_07420), Quinolinate synthase (HPMKM5_0045), Quinolinate synthase (BB415_07315), Quinolinate synthase (BGL82_01035), Quinolinate synthase (ACM23_00975), Quinolinate synthase (EG63_06695), Quinolinate synthase (HPF63_0047), Quinolinate synthase (BB400_07225), Quinolinate synthase (HPF75_0049), Quinolinate synthase A (nadA), Quinolinate synthase (BB411_06835), Quinolinate synthase (ACM27_07100), Quinolinate synthase (CGC32_07160), Quinolinate synthase (BB408_07620), Quinolinate synthase (HPY173_04020), Quinolinate synthase (HPF211_0044), Quinolinate synthase (BB459_06300), Quinolinate synthase (AOD76_0201075), Quinolinate synthase (BB451_03970), Quinolinate synthase (HPY655_06365), Quinolinate synthase A (nadA), Quinolinate synthase (BB398_07655), Quinolinate synthase (BB414_04340), Quinolinate synthase (BB404_07050), Quinolinate synthase (BB413_07120), Quinolinate synthase (BZK18_04270), Quinolinate synthase (BGL70_03090), Quinolinate synthase (BB407_01115), Quinolinate synthase (BHU51_02520), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB433_07695), Quinolinate synthase (HPF72_0043), Quinolinate synthase (BB469_07440), Quinolinate synthase A (nadA), Quinolinate synthase (BB468_06445), Quinolinate synthase (HPY1786_06525), Quinolinate synthase (BV499_07240), Quinolinate synthase (BB384_07435), Quinolinate synthase (BB396_07710), Quinolinate synthase (BGL87_02485), Quinolinate synthase (BGL78_02880), Quinolinate synthase (BGL75_01500), Quinolinate synthase (BZK22_08035), Quinolinate synthase A (nadA), Quinolinate synthase (AV921_0207375), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB454_05770), Quinolinate synthase (AOD77_0202490)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25IminoaspartateUniRule annotation1
Binding sitei42Iminoaspartate; via amide nitrogenUniRule annotation1
Binding sitei117IminoaspartateUniRule annotation1
Binding sitei138IminoaspartateUniRule annotation1
Binding sitei224IminoaspartateUniRule annotation1
Binding sitei241IminoaspartateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation
Ligand4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
ORF Names:BGL65_01145Imported, BGL80_06145Imported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000220551 Componenti: Unassembled WGS sequence
  • UP000220247 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 3 subfamily.UniRule annotation

Family and domain databases

HAMAPiMF_00569 NadA_type3, 1 hit
InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
IPR023515 Quinolinate_synth_A_type3
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A293T0K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTDNDLKTS IVELLNDLDA LLVAHFYQKD EIVELAHHTG DSLELAKIAS
60 70 80 90 100
QSDKNLIVFC GVHFMGESVK ALAFNKQVIM PKLSCCSMAR MIDSHYYDRS
110 120 130 140 150
VHLLKEYGVK EFYPITYINS NAEVKAKVAK DDGVVCTSRN ASKIFNHALK
160 170 180 190 200
QNKKIFFLPD KCLGENLALE NGLKSAILGV NSPEEIQNAD VVCYNGFCSV
210 220 230 240 250
HQLFKLEDIE FYRQKYPDIL IAVHPECEPS VVSNADFSGS TSQIIEFVEK
260 270 280 290 300
LSPDQKVAIG TESHLVNRLK AKRHHQNTFI LSSTLALCPT MNETTLKDLF
310 320 330
EVLKAYKNHR AYNAIELKDE VARLAKLALT RMMELS
Length:336
Mass (Da):37,804
Last modified:December 20, 2017 - v1
Checksum:i3F6997657DF17180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MILC01000024 Genomic DNA Translation: OPG34851.1
MILR01000063 Genomic DNA Translation: OPG57815.1

Similar proteinsi

Entry informationi

Entry nameiA0A293T0K7_HELPX
AccessioniPrimary (citable) accession number: A0A293T0K7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported