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Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Hydrogenobacter hydrogenophilus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotationSAAS annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (SAMN06265353_1013)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (SAMN06265353_1013)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9SubstrateUniRule annotation1
Binding sitei17ATPUniRule annotation1
Sitei17Transition state stabilizerUniRule annotation1
Binding sitei74Substrate; via amide nitrogenUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei99ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 10ATPUniRule annotation2
Nucleotide bindingi89 – 91ATPUniRule annotation3
Nucleotide bindingi123 – 129ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processCoenzyme A biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
ORF Names:SAMN06265353_0759Imported
OrganismiHydrogenobacter hydrogenophilusImported
Taxonomic identifieri35835 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
Proteomesi
  • UP000218627 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homohexamer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 133CTP_transf_likeInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the bacterial CoaD family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02163. PPAT. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00151. PPAT_bact. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR001980. PPAT.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21342:SF1. PTHR21342:SF1. 1 hit.
PfamiView protein in Pfam
PF01467. CTP_transf_like. 1 hit.
PRINTSiPR01020. LPSBIOSNTHSS.
TIGRFAMsiTIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A285NW29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVVYPGTF DPPHLGHLDI VKRSCEVFDR VVVAVARNPR RHLLFNMEER
60 70 80 90 100
VEMFKKMVEC LGDKVEVKGF DGLLVNFMLE EGIRLIVRGV RLFTDFEYEL
110 120 130 140 150
QIAMNNYKLA KVETIFMMPS QDYIHISSTI VRDIASYCGD LKGLVHPYVE
160
EKLKEKFGCF KM
Length:162
Mass (Da):18,842
Last modified:November 22, 2017 - v1
Checksum:i77CB2F1768066817
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
OBEN01000002 Genomic DNA. Translation: SNZ13438.1.

Similar proteinsi

Entry informationi

Entry nameiA0A285NW29_9AQUI
AccessioniPrimary (citable) accession number: A0A285NW29
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: February 28, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported