Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Bacillus clausii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6IronUniRule annotation1
Sitei66Transition state stabilizerUniRule annotation1
Metal bindingi76Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotationImported, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-degrading monooxygenaseUniRule annotation (EC:1.14.14.18UniRule annotation)
Alternative name(s):
Heme oxygenaseUniRule annotation
Iron-regulated surface determinantUniRule annotation
Iron-responsive surface determinantUniRule annotation
Gene namesi
Name:isdGUniRule annotation
ORF Names:CHH72_08945Imported
OrganismiBacillus clausiiImported
Taxonomic identifieri79880 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000216207 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

SMRiA0A268P0X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93ABMInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation

Family and domain databases

HAMAPiMF_01272. Heme_degrading_monooxygenase. 1 hit.
InterProiView protein in InterPro
IPR007138. ABM_dom.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
PfamiView protein in Pfam
PF03992. ABM. 1 hit.
SUPFAMiSSF54909. SSF54909. 1 hit.
PROSITEiView protein in PROSITE
PS51725. ABM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A268P0X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIVANKTLI RKGEGHKLVK RFDKIGKIEM QKGFLGLEVL VNAKEKEVDE
60 70 80 90 100
VTISTRWETK ADFHAWTKSE AFREAHSGRN ARPDYILGNE IEFYDVEVVR

MPIAQAQ
Length:107
Mass (Da):12,302
Last modified:December 20, 2017 - v1
Checksum:i31ED9218A7A4B6D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NPCC01000009 Genomic DNA. Translation: PAE89404.1.
RefSeqiWP_011248264.1. NZ_NPDF01000005.1.

Genome annotation databases

GeneIDi34043504.

Similar proteinsi

Entry informationi

Entry nameiA0A268P0X8_BACCS
AccessioniPrimary (citable) accession number: A0A268P0X8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported