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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDH1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDH1), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH2), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDH1b)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:SDH1Imported
ORF Names:SCKG_3714Imported
OrganismiSaccharomyces cerevisiae (Baker's yeast)Imported
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 450FAD_binding_2InterPro annotationAdd BLAST397
Domaini505 – 640Succ_DH_flav_CInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR003953. FAD-binding_2.
IPR036188. FAD/NAD-bd_sf.
IPR003952. FRD_SDH_FAD_BS.
IPR037099. Fum_R/Succ_DH_flav-like_C_sf.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat_sf.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
PfamiView protein in Pfam
PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiView protein in PROSITE
PS00504. FRD_SDH_FAD_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A250WIF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLKKSALS KLTLLRNTRT FTSSALVRQT QGSVNGSASR SADGKYHIID
60 70 80 90 100
HEYDCVVIGA GGAGLRAAFG LAEAGYKTAC ISKLFPTRSH TVAAQGGINA
110 120 130 140 150
ALGNMHKDNW KWHMYDTVKG SDWLGDQDSI HYMTREAPKS IIELEHYGVP
160 170 180 190 200
FSRTENGKIY QRAFGGQTKE YGKGAQAYRT CAVADRTGHA LLHTLYGQAL
210 220 230 240 250
RHDTHFFIEY FALDLLTHNG EVVGVIAYNQ EDGTIHRFRA HKTIIATGGY
260 270 280 290 300
GRAYFSCTSA HTCTGDGNAM VSRAGFPLQD LEFVQFHPSG IYGSGCLITE
310 320 330 340 350
GARGEGGFLV NSEGERFMER YAPTAKDLAC RDVVSRAITM EIREGRGVGK
360 370 380 390 400
KKDHMYLQLS HLPPEVLKER LPGISETAAI FAGVDVTKEP IPIIPTVHYN
410 420 430 440 450
MGGIPTKWNG EALTIDEETG EDKVIPGLMA CGEAACVSVH GANRLGANSL
460 470 480 490 500
LDLVVFGRAV AHTVADTLQP GLPHKPLPSD LGKESIANLD KLRNANGSRS
510 520 530 540 550
TAEIRMNMKQ TMQKDVSVFR TQSSLDEGVR NITAVEKTFD DVKTTDRSMI
560 570 580 590 600
WNSDLVETLE LQNLLTCASQ TAVSAANRKE SRGAHAREDY PNRDDEHWMK
610 620 630 640
HTLSWQKDVA APVTLKYRRV IDHTLDEKEC PSVPPTVRAY
Length:640
Mass (Da):70,229
Last modified:November 22, 2017 - v1
Checksum:iA657E440B8ED58E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BEGW01000009 Genomic DNA. Translation: GAX70613.1.

Similar proteinsi

Entry informationi

Entry nameiA0A250WIF8_YEASX
AccessioniPrimary (citable) accession number: A0A250WIF8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: December 20, 2017
This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported