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Protein

DnaA regulatory inactivator Hda

Gene

hda

Organism
Lelliottia sp. PFL01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionDNA replication inhibitorUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DnaA regulatory inactivator HdaUniRule annotationSAAS annotation
Gene namesi
Name:hdaUniRule annotation
ORF Names:LJPFL01_3036Imported
OrganismiLelliottia sp. PFL01Imported
Taxonomic identifieri1907578 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeLelliottia
Proteomesi
  • UP000215339 Componenti: Chromosome

Interactioni

Subunit structurei

The active form seems to be an ADP-bound monomer. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 228Bac_DnaAInterPro annotationAdd BLAST197

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili210 – 230Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the DnaA family. HdA subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK10763

Family and domain databases

HAMAPiMF_01158 Hda, 1 hit
InterProiView protein in InterPro
IPR020591 Chromosome_initiator_DnaA-like
IPR013317 DnaA
IPR017788 Hda
IPR022864 Hda_Enterobact
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PRINTSiPR00051 DNAA
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03420 DnaA_homol_Hda, 1 hit

Sequencei

Sequence statusi: Complete.

A0A248T1Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINSLPILCE TLIEVFLNGP AQLSLPLYLP DDETFASFWP GDNPSLLAAL
60 70 80 90 100
QNVLRQEHSG YIYIWSREGA GRSHLLHAAC AELSQRGDAV GYVPLDKRTW
110 120 130 140 150
FVPEVLDGME HLSLVCIDNI ECIAGDELWE MAMFNLYNRI LESGKTRLLI
160 170 180 190 200
TGDRPPRQLN LGLPDLASRL DWGQIYKLQP LSDEDKLQAL QLRSRLRGFE
210 220 230 240
LPEDVGRFLL KRLDREMRTL FDTLDQLDRA SITAQRKLTI PFVKETLKL
Length:249
Mass (Da):28,419
Last modified:December 20, 2017 - v1
Checksum:i1D418F2E304A4522
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP018628 Genomic DNA Translation: ASV56399.1

Genome annotation databases

KEGGilef:LJPFL01_3036

Similar proteinsi

Entry informationi

Entry nameiA0A248T1Y9_9ENTR
AccessioniPrimary (citable) accession number: A0A248T1Y9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: March 28, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health