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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic

Gene

accD

Organism
Solanum pennellii (Tomato) (Lycopersicon pennellii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi242ZincUniRule annotation1
Metal bindingi245ZincUniRule annotation1
Metal bindingi261ZincUniRule annotation1
Metal bindingi264ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri242 – 264C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation, TransferaseImported
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotationImported
Encoded oniPlastid; ChloroplastImported
OrganismiSolanum pennellii (Tomato) (Lycopersicon pennellii)Imported
Taxonomic identifieri28526 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChloroplastImported, Plastid

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).SAAS annotation
Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 507CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri242 – 264C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A223A6V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHLLYFHA NRGQENSMER WWFNSMLFKK EFERRCGLNK SMGSLGPIEN
60 70 80 90 100
TSEDPNLKVK NIHSCSNVDY LFGIKDIWNF ISNDTFLVSD RNGDSYSIYF
110 120 130 140 150
DIENHIFEVD NDHSFLSELE SSFYSYRNSS YLNNGFRGED PYYNSYMSYM
160 170 180 190 200
YDTQYSWNNH INSCIDNYLQ SQICIDTSII SGSESYGDSY IYRAICSGQS
210 220 230 240 250
LNSSENEGSS RRTRTKDSDL TIRESSNDLE VTQKYKHLWV QCENCYGLNY
260 270 280 290 300
KKFFKSKMNI CEQCGYHLKM SSSDRIELLI DPGTWDPMDE DMVSLDPIEF
310 320 330 340 350
HSEEEPYKDR IDSYQRKTGL TEAVQTGIGQ LNGIPVAIGV MDFQFMGGSM
360 370 380 390 400
GSVVGEKITR LIEHAANQNL PLMIVCASGG ARMQEGSLSL MQMAKISSAL
410 420 430 440 450
YDYQLNKKLF YVSILTSPTT GGVTASFGML GDIIIAEPNA YIAFAGKRVI
460 470 480 490 500
EQTLNKTVPE GSQAAEYLFQ KGLFDLIVPR NLLKSVLSEL FKLHAFFPLN

QKSSKIK
Length:507
Mass (Da):57,784
Last modified:October 25, 2017 - v1
Checksum:i0358E6EF2EB87196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY887589 Genomic DNA. Translation: ASR92602.1.

Similar proteinsi

Entry informationi

Entry nameiA0A223A6V3_SOLPN
AccessioniPrimary (citable) accession number: A0A223A6V3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2017
Last sequence update: October 25, 2017
Last modified: December 20, 2017
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)