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Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Arthrobacter sp. YN
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotationSAAS annotation

Catalytic activityi

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotationSAAS annotation

Cofactori

Mn2+SAAS annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processMenaquinone biosynthesisUniRule annotation
LigandMagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00164.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotationSAAS annotation (EC:2.2.1.9UniRule annotation)
Short name:
SEPHCHC synthaseUniRule annotation
Alternative name(s):
Menaquinone biosynthesis protein MenDUniRule annotation
Gene namesi
Name:menDUniRule annotationImported
ORF Names:CGK93_17660Imported
OrganismiArthrobacter sp. YNImported
Taxonomic identifieri2020486 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000199745 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 179TPP_enzyme_NInterPro annotationAdd BLAST167
Domaini404 – 535TPP_enzyme_CInterPro annotationAdd BLAST132

Sequence similaritiesi

Belongs to the TPP enzyme family. MenD subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK02551.

Family and domain databases

HAMAPiMF_01659. MenD. 1 hit.
InterProiView protein in InterPro
IPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR011766. TPP_enzyme-bd_C.
PANTHERiPTHR42916. PTHR42916. 1 hit.
PfamiView protein in Pfam
PF02775. TPP_enzyme_C. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
PIRSFiPIRSF004983. MenD. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00173. menD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A221NMY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQDSLTSI GAARIAVTAL LDGGVRHVVV APGSRSAPMA YALAEAEASG
60 70 80 90 100
RVRLHVRIDE RDAGFTALGL ALSTEAPVAV VTTSGTAVGN LLPAVMEANH
110 120 130 140 150
SAVPVVVISA DRPEELHGTG ANQTTTQLDL FGDHVRFAVD VPAGDHPQKA
160 170 180 190 200
VATALYAATG ALEDTPPGPV QVNLAFRDPL VPAPGDALPV AAGHGVFHYD
210 220 230 240 250
AGPQALVLPE ASTALPERRT VVLAGHDAGP VAEAFARAHG LPLLAEPSSN
260 270 280 290 300
ARFGPNAVGP YRVLLEHFGP QSPSPIERVV LFGRATLSRP VASLLARESV
310 320 330 340 350
ETAIYQPVPV AWYEAGRRRE TPIETLPGLA EFAGRGSAEW LDSWLLAGAA
360 370 380 390 400
AQHGLDGVLA GETLASGPSV GATVWEHSRG QLVLGSSNGI RDVDLAGQPH
410 420 430 440 450
TDPIASVYAN RGLAGIDGTI ATATGIALGS GRETTVLLGD VTFLHDAGGL
460 470 480 490 500
LLGHREPVPD LRIVVLNDAG GAIFSLLEHG AVEDSGAYGT AVERLFGTPH
510 520 530 540 550
SVDIAALAAA YGVGHQAVST TAELASALKA PLKGRSIVEV RVDRTGLRAL
560
HGRIKEAISA AVGQVLTAG
Length:569
Mass (Da):58,290
Last modified:October 25, 2017 - v1
Checksum:i23ED69EB807F7C05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP022436 Genomic DNA. Translation: ASN21307.1.

Genome annotation databases

KEGGiarn:CGK93_17660.

Similar proteinsi

Entry informationi

Entry nameiA0A221NMY9_9MICC
AccessioniPrimary (citable) accession number: A0A221NMY9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2017
Last sequence update: October 25, 2017
Last modified: February 28, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported