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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Shewanella bicestrii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotationSAAS annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotationSAAS annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotationSAAS annotation (EC:2.4.2.4UniRule annotationSAAS annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotationImported
ORF Names:CF168_15525Imported
OrganismiShewanella bicestriiImported
Taxonomic identifieri2018305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000198367 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A220UQE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 424PYNP_CInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00758.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
3.90.1170.30. 1 hit.
HAMAPiMF_01628. Thymid_phosp. 1 hit.
InterProiView protein in InterPro
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR036320. Glycosyl_Trfase_fam3_N_dom)sf.
IPR035902. Nuc_phospho_transferase.
IPR036566. PYNP-like_C_sf.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR017872. Pyrmidine_PPase_CS.
IPR000053. Thymidine/pyrmidine_PPase.
IPR013465. Thymidine_Pase.
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiView protein in Pfam
PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiView protein in SMART
SM00941. PYNP_C. 1 hit.
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEiView protein in PROSITE
PS00647. THYMID_PHOSPHORYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A220UQE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAQEIIRK KRNGLALSTE EIQFFVKGIT TNAVSEGQIA ALGMAVYFND
60 70 80 90 100
MNMDERIALT TAMRDSGTVL NWQSLGLNGP VIDKHSTGGV GDVISLMLGP
110 120 130 140 150
MAAACGGYVP MISGRGLGHT GGTLDKFDAI PGYQTEPSSE LFRKVVKDVG
160 170 180 190 200
VAIIGQTGDL VPADKRFYSI RDNTATVESI SLITASILSK KLACSLDALA
210 220 230 240 250
MDVKVGSGAF MPTYEASEEL ARSIAAVANG AGTKTTALLT DMNQVLASCA
260 270 280 290 300
GNAVEVKEAI DFLTGAYRNP RLYAVTMGLC AEMLLLGGLA TDEADARAKL
310 320 330 340 350
NRVLDNGRAA EIFGKMVSGL GGPVDFVENY SKYLPQSQII RPVFADTQGY
360 370 380 390 400
AHSMDTRELG LAVVTLGGGR RKPGDALDYS VGLTQVCALG DKIDASTPIA
410 420 430 440
VIHAQSEDAF AQAEEAVKKA IRIDEVAPEK TPEIYAYIRA ADL
Length:443
Mass (Da):46,864
Last modified:November 22, 2017 - v1
Checksum:iC5376AF555F29CE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP022358 Genomic DNA. Translation: ASK70151.1.
RefSeqiWP_011625502.1. NZ_CP022358.1.

Genome annotation databases

KEGGisbj:CF168_15525.

Similar proteinsi

Entry informationi

Entry nameiA0A220UQE1_9GAMM
AccessioniPrimary (citable) accession number: A0A220UQE1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported