panC

Functionⁱ

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityⁱ

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayⁱ: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:

Pantothenate synthetase (panC)

This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	37	Proton donorUniRule annotation	1
Binding siteⁱ	60	Beta-alanineUniRule annotation	1
Binding siteⁱ	60	PantoateUniRule annotation	1
Binding siteⁱ	152	PantoateUniRule annotation	1
Binding siteⁱ	175	ATP; via amide nitrogen and carbonyl oxygenUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	30 – 37	ATPUniRule annotation	8
Nucleotide bindingⁱ	146 – 149	ATPUniRule annotation	4
Nucleotide bindingⁱ	183 – 186	ATPUniRule annotation	4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
pantoate-beta-alanine ligase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

pantothenate biosynthetic process Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	LigaseUniRule annotationSAAS annotationImported
Biological process	Pantothenate biosynthesisUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00028; UER00005.

UniPathwayⁱ

UPA00028; UER00005.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation) Short name: PSUniRule annotation Alternative name(s): Pantoate--beta-alanine ligaseUniRule annotation Pantoate-activating enzymeUniRule annotation
Gene namesⁱ	Name:panCUniRule annotation ORF Names:K709_1441Imported
Organismⁱ	Campylobacter coli HN-CCD07046Imported
Taxonomic identifierⁱ	1318632 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter coli

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00158
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00573540

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationSAAS annotation

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Structureⁱ

3D structure databases

SMRⁱ	A0A212GH19.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00560. PanC. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC. 1 hit.
InterProⁱ	View protein in InterPro IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold.
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsⁱ	TIGR00018. panC. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A212GH19-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MQVITSVKEA KQIVKDWKSH QLSIGYVPTM GFLHDGHLSL VKHAKTQDKV 
        60         70         80         90        100
IVSIFVNPMQ FGPNEDFSSY PRDLERDIKM CQDNGVDMVF IPDATQMYLK 
       110        120        130        140        150
NFSTYVDMNT ITDKLCGAKR PGHFRGVCTV LTKFFNILNP DIVYMGQKDA 
       160        170        180        190        200
QQCVVVRHMV DDLNFDLKIQ ICPIIREEDG LAKSSRNVYL SKEERKASLA 
       210        220        230        240        250
ISQSIFLAEK LVREGEKNTS KIIQAMKDIL EKEKLIKIDY IELVDFNTME 
       260        270        280 
NIENITDNVL GAVAAFVGKT RLIDNFLVQG LK

Length:282

Mass (Da):32,087

Last modified:September 27, 2017 - v1

Checksum:ⁱC8946F933D7B6475

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KZ253944 Genomic DNA. Translation: OWT31141.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_002778123.1. NZ_KZ253944.1.

Genome annotation databases

GeneIDⁱ	31370091.

GeneIDⁱ

31370091.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A212GH19	A8FK86 Q9PIK2 A0A0W8KQ10 A0A0W8L8K7 A0A212GEJ5 A0A0W8L4K3 A0A0W8LCP9 A0A2K1WCQ4 A0A1E7PL50 A0A0B6U0R8 +7	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) Campylobacter jejuni HB-CJGB-LXC Campylobacter jejuni BJ-CJGB96G25 Campylobacter coli JL-CDD-LMH Campylobacter jejuni BJ-CJGB95377 Campylobacter jejuni BJ-CJGB96114 Campylobacter jejuni HB-CJGB-ZB Campylobacter jejuni Campylobacter jejuni subsp. jejuni And more	282	UniRef100_A8FK86	Cluster: Pantothenate synthetase	18

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A212GH19	A1VY17 A8FK86 Q9PIK2 A0A0W8KQ10 A0A0W8L8K7 A0A212GEJ5 A0A0W8L4K3 A0A0W8LCP9 A0A2K1WCQ4 A0A1E7PL50 +137	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) Campylobacter jejuni HB-CJGB-LXC Campylobacter jejuni BJ-CJGB96G25 Campylobacter coli JL-CDD-LMH Campylobacter jejuni BJ-CJGB95377 Campylobacter jejuni BJ-CJGB96114 Campylobacter jejuni HB-CJGB-ZB Campylobacter jejuni And more	282	UniRef90_A1VY17	Cluster: Pantothenate synthetase	148

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A212GH19	A1VY17 UPI000257D825 UPI0007408C5B UPI00046A98D8 UPI0005B3DA81 UPI0007172337 UPI0005CB7DE2 UPI00092FB32E UPI000699786B UPI00094D9E31 +167	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) Campylobacter coli Campylobacter Campylobacter jejuni Campylobacter jejuni (strain RM1221) Campylobacter sp. 110 Campylobacter coli RM4661 Campylobacter jejuni HB-CJGB-XWM Campylobacter jejuni subsp. jejuni Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97) And more	282	UniRef50_A1VY17	Cluster: Pantothenate synthetase	178

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KZ253944 Genomic DNA. Translation: OWT31141.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_002778123.1. NZ_KZ253944.1.

3D structure databases

SMRⁱ	A0A212GH19.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	31370091.

GeneIDⁱ

31370091.

Enzyme and pathway databases

UniPathwayⁱ	UPA00028; UER00005.

UniPathwayⁱ

UPA00028; UER00005.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00560. PanC. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC. 1 hit.
InterProⁱ	View protein in InterPro IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold.
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsⁱ	TIGR00018. panC. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A212GH19_CAMCO
Accessionⁱ	A0A212GH19Primary (citable) accession number: A0A212GH19
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 27, 2017
	Last sequence update:	September 27, 2017
	Last modified:	November 22, 2017
	This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - A0A212GH19 (A0A212GH19_CAMCO)

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Pantothenate synthetase

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Functionⁱ

Miscellaneous

Catalytic activityⁱ

Pathwayⁱ: (R)-pantothenate biosynthesis

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A212GH19 (A0A212GH19_CAMCO)

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Pantothenate synthetase

panC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-pantothenate biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Pathwayⁱ: (R)-pantothenate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ