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Protein

Multifunctional fusion protein

Gene

trpC

Organism
Shewanella sp. FDAARGOS_354
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotationSAAS annotation
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (CEQ32_01735)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Multifunctional fusion protein (trpC)
  4. Multifunctional fusion protein (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, IsomeraseUniRule annotationImported, Lyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042
UPA00035; UER00043

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpCUniRule annotation
Synonyms:trpFUniRule annotation
ORF Names:CEQ32_01720Imported
OrganismiShewanella sp. FDAARGOS_354Imported
Taxonomic identifieri1930557 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000197056 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 282IGPSInterPro annotationAdd BLAST246
Domaini287 – 491PRAIInterPro annotationAdd BLAST205

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation
Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

KOiK13498

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_00134_B IGPS_B, 1 hit
MF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 2 hits
PROSITEiView protein in PROSITE
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1Z4A7K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMAQVQQPE AHRSEDNQAS QDVRGSMQTS TAKANVLTRI VDTKAAHIAA
60 70 80 90 100
LKLRFPEDSL TPKISDRSLF AALKAPKAGY ILECKKASPS KGLIRKDFDV
110 120 130 140 150
EAIASIYTQY AAGISVLTDE QFFQGDMDYI PKVRAKVSQP ILCKDFFVDE
160 170 180 190 200
YQIKLAAHQG ADAILLMLSV LDDERYQQLA NEAAKYQLDV LTEVSNEEEL
210 220 230 240 250
ERAIALNAPI IGINNRNLRD LSTDLATTEA LAPHIGSDRV VISESGIYTN
260 270 280 290 300
DQVRRLSPLV DGFLVGSSIM AEEDIDLACR KLIFGHNKVC GLTRLEDIQA
310 320 330 340 350
AATAGAVYAG LIFAEKSPRA LTKDAAKQLV QQYRAANLPA IEFVGVFVNS
360 370 380 390 400
TPEFMASIAQ ECGLATLQLH GSETELEIAE LSQLLQQAGL STQIWKAVSV
410 420 430 440 450
DAQSGELAAM PRGVQRYLFD SKNDAGFGGT GQAFDWQLPI AHKAEAMLAG
460 470 480 490
GLNADNAARA NAQGFYGLDF NSGLETAPGI KSAEKIQAAF SQLRL
Length:495
Mass (Da):53,617
Last modified:November 22, 2017 - v1
Checksum:i11D13C34789D94F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP022089 Genomic DNA Translation: ASF13879.1

Genome annotation databases

KEGGishf:CEQ32_01720

Similar proteinsi

Entry informationi

Entry nameiA0A1Z4A7K3_9GAMM
AccessioniPrimary (citable) accession number: A0A1Z4A7K3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health