Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidine ammonia-lyase

Gene

hutH

Organism
Bacillus subtilis subsp. subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidine = urocanate + NH3.UniRule annotationSAAS annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (hutH), Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI), Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processHistidine metabolismUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00379; UER00549.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine ammonia-lyaseUniRule annotationSAAS annotation (EC:4.3.1.3UniRule annotationSAAS annotation)
Short name:
HistidaseUniRule annotation
Gene namesi
Name:hutHUniRule annotationImported
ORF Names:S100757_04015Imported
OrganismiBacillus subtilis subsp. subtilisImported
Taxonomic identifieri135461 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000196400 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki141 ↔ 1435-imidazolinone (Ala-Gly)UniRule annotation
Modified residuei1422,3-didehydroalanine (Ser)UniRule annotation1

Post-translational modificationi

Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.UniRule annotation
Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PAL/histidase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00332. PAL-HAL. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00229. His_ammonia_lyase. 1 hit.
InterProiView protein in InterPro
IPR001106. Aromatic_Lyase.
IPR024083. Fumarase/histidase_N.
IPR005921. HutH.
IPR008948. L-Aspartase-like.
IPR022313. Phe/His_NH3-lyase_AS.
PANTHERiPTHR10362. PTHR10362. 1 hit.
PfamiView protein in Pfam
PF00221. Lyase_aromatic. 1 hit.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR01225. hutH. 1 hit.
PROSITEiView protein in PROSITE
PS00488. PAL_HISTIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1Y0U4U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLDGSSLT TADVARVLFD FEEAAASEES MERVKKSRAA VERIVRDEKT
60 70 80 90 100
IYGINTGFGK FSDVLIQKED SAALQLNLIL SHACGVGDPF PECVSRAMLL
110 120 130 140 150
LRANALLKGF SGVRAELIEQ LLAFLNKRVH PVIPQQGSLG ASGDLAPLSH
160 170 180 190 200
LALALIGQGE VFFEGERMPA MTGLKKAGIQ PVTLTSKEGL ALINGTQAMT
210 220 230 240 250
AMGVVAYIEA EKLAYQTERI ASLTIEGLQG IIDAFDEDIH SARGYQEQID
260 270 280 290 300
VAERFRFYLS DSGLTTSQGE LRVQDAYSLR CIPQVHGATW QTLGYVKEKL
310 320 330 340 350
EIEMNAATDN PLIFNDGDKV ISGGNFHGQP IAFAMDFLKI AISELANIAE
360 370 380 390 400
RRIERLVNPQ LNDLPPFLSP HPGLQSGAMI MQYAAASLVS ENKTLAHPAS
410 420 430 440 450
VDSIPSSANQ EDHVSMGTIA ARHAYQVIAN TRRVIAIEAI CALQAVEYRG
460 470 480 490 500
IEHAASYTKQ LFQEMRKVVP SIQQDRVFSY DIERLTDWLK KESLIPDHQN

KELRGMNI
Length:508
Mass (Da):55,683
Last modified:August 30, 2017 - v1
Checksum:i3BA6513DAE2FEBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP021499 Genomic DNA. Translation: ARW04917.1.
RefSeqiWP_046161038.1. NZ_CP021889.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1Y0U4U9_BACIU
AccessioniPrimary (citable) accession number: A0A1Y0U4U9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2017
Last sequence update: August 30, 2017
Last modified: March 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported