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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Bacillus subtilis subsp. subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh), L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei124NAD or substrateUniRule annotation1
Binding sitei155SubstrateUniRule annotation1
Active sitei179Proton acceptorUniRule annotation1
Binding sitei233SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 43NADUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
ORF Names:S100757_00347Imported
OrganismiBacillus subtilis subsp. subtilisImported
Taxonomic identifieri135461 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000196400 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1Y0TUE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNKHVNKVA LIGAGFVGSS YAFALINQGI TDELVVIDVN KEKAMGDVMD
60 70 80 90 100
LNHGKAFAPQ PVKTSYGTYE DCKDADIVCI CAGANQKPGE TRLELVEKNL
110 120 130 140 150
KIFKGIVNEV MASGFDGIFL IATNPVDILT YATWKFSGLP KERVIGSGTT
160 170 180 190 200
LDSARFRFML SEYFGAAPQN VHAHIIGEHG DTELPVWSHA NVGGVPVSEL
210 220 230 240 250
VEKNDAYKQE ELDQIVDDVK NAAYHIIEKK GATYYGVAMS LARITKAILH
260 270 280 290 300
NENSILTVST YLDGQYGADD VYIGVPAVVN RGGIAGITEL NLNEKEKEQF
310 320
LHSAGVLKNI LKPHFAEQKV N
Length:321
Mass (Da):34,974
Last modified:August 30, 2017 - v1
Checksum:iA170FE49855193EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP021499 Genomic DNA Translation: ARW01313.1
RefSeqiWP_046160029.1, NZ_CP021889.1

Similar proteinsi

Entry informationi

Entry nameiA0A1Y0TUE5_BACIU
AccessioniPrimary (citable) accession number: A0A1Y0TUE5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2017
Last sequence update: August 30, 2017
Last modified: March 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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