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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Bacillus sp. CC120222-01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi108ZincUniRule annotation1
Metal bindingi110ZincUniRule annotation1
Metal bindingi135ZincUniRule annotation1
Metal bindingi137ZincUniRule annotation1
Binding sitei255ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
ORF Names:SAMN02744787_0142Imported
OrganismiBacillus sp. CC120222-01Imported
Taxonomic identifieri1378089 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000192908 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 323tRNA-synt_1cInterPro annotationAdd BLAST320

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi252 – 256"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Family and domain databases

CDDicd00808. GluRS_core. 1 hit.
Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00022. Glu_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR033910. GluRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1X7FQE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEVRVRYA PSPTGHLHIG NARTALFNYL FARNQGGKFI IRVEDTDKKR
60 70 80 90 100
NIEGGEQSQL NYLKWLGIDW DESVDVGGEY GPYRQSERND IYKVYYEELL
110 120 130 140 150
EKGLAYKCYC TEEELEKERE EQIARGEMPR YSGKHRDLTQ EEQEKFIAEG
160 170 180 190 200
RKPSIRFRVP EGKIIAFNDI VKGEISFESD GIGDFVIVKK DGTPTYNFAV
210 220 230 240 250
AIDDYLMKMT HVLRGEDHIS NTPKQIMIYQ AFGWDIPQFG HMTLIVNESR
260 270 280 290 300
KKLSKRDESI IQFIEQYKEL GYLPEALFNF IGLLGWSPVG EEELFTKEQF
310 320 330 340 350
IEIFDVNRLS KSPALFDMHK LKWVNNQYVK KLDLDQVVEL TLPHLQKAGK
360 370 380 390 400
VGTELSAEEQ EWVRKLISLY HEQLSYGAEI VELTDLFFTD EIEYNQEAKA
410 420 430 440 450
VLEEEQVPEV LSTFAAKLEE LEEFTPDNIK ASIKAVQKET GHKGKKLFMP
460 470 480
IRVAVTGQTH GPELPQSIEL IGKETAIQRL KNI
Length:483
Mass (Da):55,736
Last modified:July 5, 2017 - v1
Checksum:i289DB3E8FBA557EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FWZZ01000012 Genomic DNA. Translation: SMF56774.1.
RefSeqiWP_014478617.1. NZ_FWZZ01000012.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1X7FQE3_9BACI
AccessioniPrimary (citable) accession number: A0A1X7FQE3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: March 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported