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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Mycobacterium wolinskyi
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA), Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL), Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseImported, IsomeraseUniRule annotationSAAS annotation, Transferase
Biological processPorphyrin biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
ORF Names:AWC31_03125Imported
OrganismiMycobacterium wolinskyiImported
Taxonomic identifieri59750 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000193964 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.101 hit
3.90.1150.102 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1X2EYB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAHSAQTQR SAQLFADACA VIPGGVNSPV RAFNSVGGTP RFITSANGYW
60 70 80 90 100
LTDADGNRYV DLVCSWGPML LGHAHPAVVE AVQKVAVDGL SFGAPTPSET
110 120 130 140 150
ELAAEIIDRV APVEMLRLVN SGTEATMSAI RLARGYTGRA KIIKFSGCYH
160 170 180 190 200
GHSDALLADA GSGVATLGLP SSPGVTGAAA ADTIVLPYNN VAAVEEVFGR
210 220 230 240 250
FGDEIACVIS EASPGNMGTV PPLPGFNAAL RRITAEHGAL LILDEVMTGF
260 270 280 290 300
RVSRSGWYGI DHVEADLLTF GKVMSGGLPA AAFGGSAEVM GRLAPLGPVY
310 320 330 340 350
QAGTLSGNPV AMAAGLATLR NADDAAYARV DANADRLADL LTGALTEASV
360 370 380 390 400
AHRVQRAGNM LSVFFTDEPV NDFAAAKATE TWRFPAFFHA LLEAGVYPPC
410 420 430
SAFETWFVSA ALDDDAFSRI ADALPAAARA AAEAAA
Length:436
Mass (Da):45,125
Last modified:July 5, 2017 - v1
Checksum:i6A53B81303A03BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LQQA01000031 Genomic DNA Translation: ORX11134.1

Similar proteinsi

Entry informationi

Entry nameiA0A1X2EYB5_9MYCO
AccessioniPrimary (citable) accession number: A0A1X2EYB5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: March 28, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported