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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium saskatchewanense
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationImported, Transferase
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
ORF Names:AWC23_15085Imported
OrganismiMycobacterium saskatchewanenseImported
Taxonomic identifieri220927 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000193387 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF01983. CofC. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1X2C5J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTRAGGAG EVALIIAVKR LAAAKTRLAP VFSPRTRESV VLAMLVDTLT
60 70 80 90 100
AASRVRAVGS ITVITPDAAA AAAAAELGAE VLDDPTPEGH NDPLNNAIGA
110 120 130 140 150
AERSVADSFA NFVVLQGDLP ALQSQELAEA IGAARQHRRS FVADRLATGT
160 170 180 190 200
SALCAFGTAL DPHFGADSAA RHRHSGAIEL TGAWPGLRCD VDTPADLAAA
210
RQLGVGPATA RTLAHH
Length:216
Mass (Da):22,006
Last modified:July 5, 2017 - v1
Checksum:i70E43BEE42AD04A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LQPR01000035 Genomic DNA. Translation: ORW71091.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1X2C5J7_9MYCO
AccessioniPrimary (citable) accession number: A0A1X2C5J7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: December 20, 2017
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported