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Protein

Allantoinase

Gene

allB

Organism
Bacillus vallismortis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB), Allantoinase (allB), Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1UniRule annotation1
Metal bindingi62Zinc 1UniRule annotation1
Metal bindingi147Zinc 1; via carbamate groupUniRule annotation1
Metal bindingi147Zinc 2; via carbamate groupUniRule annotation1
Metal bindingi183Zinc 2UniRule annotation1
Metal bindingi239Zinc 2UniRule annotation1
Metal bindingi312Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPurine metabolismUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotation
ORF Names:B9C48_15070Imported
OrganismiBacillus vallismortisImported
Taxonomic identifieri72361 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000193819 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 426Amidohydro-relInterPro annotationAdd BLAST376

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.UniRule annotation

Phylogenomic databases

KOiK01466

Family and domain databases

Gene3Di2.30.40.10, 3 hits
HAMAPiMF_01645 Hydantoinase, 1 hit
InterProiView protein in InterPro
IPR017593 Allantoinase
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR03178 allantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1W6HM46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDVIVKGA KAVRKGGTER ADIAVKDGKI ALIGPGIDEN AEQVVQADGM
60 70 80 90 100
YVFPGAVDCH VHFNEPGREE WEGIETGSNM LAAGGCTSYF DMPLNCIPST
110 120 130 140 150
VTAENLLAKA EIAERKSAVD FALWGGLMPG YTEHIRPMAE AGAIGFKAFL
160 170 180 190 200
SKSGTDEFQS ADERTLLKGM KEIAACGKIL ALHAESDALT RFLEAEYALQ
210 220 230 240 250
GKIDARAYAS SRPEEAECEA VQRAIEYARA TGCALHFVHI STKRAVLSIQ
260 270 280 290 300
QAKKDGLDVT VETCPHYLLF SFEDFLKKGA AAKCAPPLRS EADKEELIGV
310 320 330 340 350
LAEGQIDMVS SDHSPCHPSL KREDNMFLSW GGISGGQFTL LGMIQLAIDH
360 370 380 390 400
GIPFEHVARW TAEAPAERFG LTNKGRLEEG FDADFAIVRP EPFTVTKETM
410 420 430 440 450
FSKHKQSLYE GRTFPYRIAA TYSKGRCVYQ DGVGKQSGAF GTFLKPSEIK

EPIL
Length:454
Mass (Da):49,418
Last modified:July 5, 2017 - v1
Checksum:iDAB3CE0DE93EA7A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP020893 Genomic DNA Translation: ARM29070.1
RefSeqiWP_032876707.1, NZ_CP020893.1

Genome annotation databases

KEGGibvm:B9C48_15070

Similar proteinsi

Entry informationi

Entry nameiA0A1W6HM46_BACVA
AccessioniPrimary (citable) accession number: A0A1W6HM46
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: February 28, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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