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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Burkholderia pseudomallei (Pseudomonas pseudomallei)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei676ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:BOC42_11160Imported
OrganismiBurkholderia pseudomallei (Pseudomonas pseudomallei)Imported
Taxonomic identifieri28450 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000193684 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 220tRNA-synt_1gInterPro annotationAdd BLAST134
Domaini269 – 456tRNA-synt_1_2InterPro annotationAdd BLAST188
Domaini470 – 625tRNA-synt_1InterPro annotationAdd BLAST156
Domaini672 – 712tRNA-synt_1InterPro annotationAdd BLAST41
Domaini753 – 875Anticodon_1InterPro annotationAdd BLAST123

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 101"HIGH" regionUniRule annotationAdd BLAST11
Motifi673 – 677"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1W6FHQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRRGRYNR RFPRAAPGRR GSATFDPLER ACARHLASCA AQKPSPNHTM
60 70 80 90 100
HERYVPADVE AAAQSDWRAA DAYRSKEDAN RKKFYCVSML PYPSGKLHMG
110 120 130 140 150
HVRNYTINDV MYRYLRMNGY NTLMPMGWDA FGMPAENAAM ANGVPPAQWT
160 170 180 190 200
YENIAYMKKQ MQSMGLAIDW SREVTTCKPD YYKWNQWLFL KMLEKGVAYK
210 220 230 240 250
KTGTVNWDPV DQTVLANEQV IDGRGWRSGA LVEKREIPMY YMRITQYADE
260 270 280 290 300
LLNDLDGLGW PERVKVMQHN WIGKSFGVNF GFPYELDGEK KLLRVFTTRA
310 320 330 340 350
DTIMGVTFCA IAAEHPLAAR LARDKPALQA FIDECKRGGV AEADIATMEK
360 370 380 390 400
KGVATGFSVS HPLTGEPVEV WIGNYVLMSY GEGAVMGVPA HDERDFAFAK
410 420 430 440 450
KYGLPIRQVI AVEGETYSTD AWQEWYGDKT RAVCVNSGKY DGLAHDAAVD
460 470 480 490 500
AIAAELKAGG LGDKQITYRL RDWGISRQRY WGTPIPIIHC PSCGDVPVPE
510 520 530 540 550
QDLPVVLPED LVPDGTGNPL AKSDAFLNCT CPKCGAAAKR ETDTMDTFVD
560 570 580 590 600
SAWYFSRYAA PDAQTMVDAR TDYWMPMDQY IGGIEHAILH LLYSRFWAKV
610 620 630 640 650
MRDLGLVAFG EPAKNLLTQG MVLNETFYRE DAAGKKTWYN PADVTVSFDD
660 670 680 690 700
KGRPVGAVLK SDGQPVELGG IEKMSKSKNN GVDPQMLIDH YGADTARLFT
710 720 730 740 750
MFAAPPEQQL EWSGAGVDGA SRFLRRVWAF GFANREALAV RAPFDAAQLA
760 770 780 790 800
EADKTLRREI HGVLKQADFD YQRLQYNTVV SAAMKMLNAI EGAKGATPAV
810 820 830 840 850
LRETYGVLLR VLYPVVPHVT FELWKALGYA DEFGPLLDAP WPKVDEAALE
860 870 880 890 900
QAEIELVLQV NGKVRGALKV AKDASREAIE AAAVADEMFA KFAEGRPAKK
910
IIVVPGRLVN VVV
Length:913
Mass (Da):101,626
Last modified:July 5, 2017 - v1
Checksum:i12C7FA571597CF60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP018380 Genomic DNA. Translation: ARK87865.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1W6FHQ2_BURPE
AccessioniPrimary (citable) accession number: A0A1W6FHQ2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: March 28, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported