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Protein
Submitted name:

glutamate receptor ionotropic, NMDA 2B

Gene

grin2b

Organism
Scleropages formosus (Asian bonytongue)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
glutamate receptor ionotropic, NMDA 2BImported
Gene namesi
Name:grin2bImported
OrganismiScleropages formosus (Asian bonytongue)Imported
Taxonomic identifieri113540 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOsteoglossocephalaOsteoglossomorphaOsteoglossiformesOsteoglossidaeScleropages
Proteomesi
  • UP000192224 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei636 – 658HelicalSequence analysisAdd BLAST23
Transmembranei708 – 730HelicalSequence analysisAdd BLAST23
Transmembranei899 – 922HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini524 – 877PBPeInterPro annotationAdd BLAST354
Domaini527 – 581Lig_chan-Glu_bdInterPro annotationAdd BLAST55

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PRINTSiPR00177. NMDARECEPTOR.
SMARTiView protein in SMART
SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1W4Z086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGLAVHKG FHFLSYTMPI HHRCSSSTPE DYRASLPVPI LESSSSRHCW
60 70 80 90 100
PPVSILFLLC LCFLLLVPFV ECRRDKGGGG SGGERGGGSH YVPVAPAPPP
110 120 130 140 150
PNKLTQGLSI AVVLVGNSSE VALAEGREKE DFQYMPLPPN VELVTMNETD
160 170 180 190 200
PKSIITCICD LMTKHWLQGV VFGDDTDQEA IAQILDFISA QTHIPILGIR
210 220 230 240 250
GGSSMIMAAK DDNSMFFQFG PSIEQQASVM LNIMEEYDWY IFSIVTTYYP
260 270 280 290 300
GNKDFVNKVR STIENSFVGW ELEEVLLLDM SVDDGDSKIQ NQLKKLQSPV
310 320 330 340 350
ILLYCTKEEA TTIFAVAHSV GLTGYGYTWI VPSLVTGDSD NVPVEFPKGL
360 370 380 390 400
ISVSYDEWDY SLEARVRDGV AIIAMATSTM MLDRGPHTLL KSECHGAPDK
410 420 430 440 450
KGSNAGNPNE VLRYLMNVTF EGRNLSFSED GYQMHPKLVI ILLDKDRQWD
460 470 480 490 500
RVGKWENGTL TMKYHVWPRF ELYPGAEERE DDHLSIVTLE EAPFVIVEDV
510 520 530 540 550
DPLSGTCMRN TVPCRKQIKG LNQTRDSGIY IKRCCKGFCI DILKKIAKSV
560 570 580 590 600
KFTYDLYLVT NGKHGKKVNG TWNGMVGEVV VKNAHMAVGS LTINEERSEV
610 620 630 640 650
IDFSVPFIET GISVMVSRSN GTVSPSAFLE PFSADVWVMM FVMLLLVSAV
660 670 680 690 700
AVFVFEYFSP VGYNRCLADG REPGGPSFTI GKAIWLLWGL VFNNSVPVQN
710 720 730 740 750
PKGTTSKIMV SVWAFFAVIF LASYTANLAA FMIQEEYVDQ VTGLSDKKFQ
760 770 780 790 800
RPNDFSPPFR FGTVPNGSTE RNIRNNYKEM HTYMVKYHQR NVDEALHSLK
810 820 830 840 850
TGKLDAFIYD AAVLNYMAGR DEGCKLVTIG SGYIFATTGY GIAIQKDSGW
860 870 880 890 900
KRQVDLAILQ LFGDGEMEEL EALWLTGICH HEKNEVMSSQ LDVDNMAGVF
910 920 930 940 950
YMLGAAMVLS LVTFICEHLF YWQLRFCFMG VCSGKPGITY SISREIYSCI
960 970 980 990 1000
HGVQIEENKS ALNSPSATMN NTHSNILRLL RTAKNMASLS GVNGSPHSAL
1010 1020 1030 1040 1050
DFIRRESSVY DISEHRRSLA GHSDCKPPYL TEDNMFSDYI SEVERTFGNL
1060 1070 1080 1090 1100
HLKDSNLYQD HYLHHHPGSG SGLALGLSGP PPNRPHSLGS ASSLEGGMFD
1110 1120 1130 1140 1150
CDSLGGGVAP IFTTQPRASL MHRNNNKFDL IAGQTPSSGQ GFKQGLTDIY
1160 1170 1180 1190 1200
GKFSFKGGAS SSGFIAGHDR YCGGGGGGGG DDGNIRSDVS DISTHTVTYG
1210 1220 1230 1240 1250
NLEGNAKKRK QYRDSLKKRP ASAKSRRELD EIELGYRRRP HHTAHHHYHG
1260 1270 1280 1290 1300
SQAHRSSSPP LFPLDRKSQR GSGGAGGNSS SYMFRDKESL RDFYLDQFRP
1310 1320 1330 1340 1350
KEGVPQWEHV DLTDGPGGSG GGLVSGGGGC SSGGVGGGGG NSSSLVPVDD
1360 1370 1380 1390 1400
FLKSKSKKAE CKSGVGGGLS QAASGPQAQG CWEKNVPGSS GGGLAGGDWE
1410 1420 1430 1440 1450
CRNCRASGGG GKQMSLHSAG GGVGGGIAYQ GGLEGGSCGA AVGGVGGGSS
1460 1470 1480 1490 1500
RPSSATCMRC DACKKTGNLY DISEDNNQLL ELEKGGIMEG VVGGAGLVQS
1510 1520 1530 1540 1550
QTQAQRRKPG LGGKPLRRQH SYDTFVDLQK EETGGVGGVM GGLGGAGGVG
1560 1570 1580 1590 1600
GGGMGGMLPP PRSVSLKDKD RFMEGGSPYA HIFERHGGSE RERERDRDPL
1610 1620 1630 1640 1650
FFGGERGKGG SPFGLFRGGE GGLHRRSVGE RDSRDRDRGM MGAGESGGGG
1660 1670 1680 1690 1700
GGAYSLSKSL YPDKVNQNPF IPTFGDDQCL LHGAKSYYVK KQQQQQQQQQ
1710 1720 1730 1740 1750
QQQQQPQLLN SRSDFRGSMG VTSFLPASAT AGVMSNVAPR FPKELCMGGA
1760 1770 1780 1790 1800
GGGIGNHLGG PGNSKLLPSR DGLGVGQAQR PFNGSSNGHV YEKLSSIESD

V
Length:1,801
Mass (Da):194,822
Last modified:June 7, 2017 - v1
Checksum:i9687530CE4B6C6C3
GO

Sequence databases

RefSeqiXP_018593946.1. XM_018738430.1.

Genome annotation databases

GeneIDi108926019.

Similar proteinsi

Entry informationi

Entry nameiA0A1W4Z086_9TELE
AccessioniPrimary (citable) accession number: A0A1W4Z086
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: September 27, 2017
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported