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Protein

Neuropilin

Gene

nrp1

Organism
Scleropages formosus (Asian bonytongue)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi192CalciumUniRule annotation1
Metal bindingi206CalciumUniRule annotation1
Metal bindingi247CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, ReceptorUniRule annotation
Biological processDifferentiationUniRule annotation, NeurogenesisUniRule annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuropilinUniRule annotation
Gene namesi
Name:nrp1Imported
OrganismiScleropages formosus (Asian bonytongue)Imported
Taxonomic identifieri113540 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOsteoglossocephalaOsteoglossomorphaOsteoglossiformesOsteoglossidaeScleropages
Proteomesi
  • UP000192224 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei847 – 872HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501074564619 – 913NeuropilinSequence analysisAdd BLAST895

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 51UniRule annotation
Disulfide bondi79 ↔ 101UniRule annotation
Disulfide bondi144 ↔ 170UniRule annotation
Disulfide bondi203 ↔ 225UniRule annotation
Disulfide bondi272 ↔ 421UniRule annotation
Disulfide bondi428 ↔ 581UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 138CUBInterPro annotationAdd BLAST115
Domaini144 – 262CUBInterPro annotationAdd BLAST119
Domaini272 – 421F5/8 type CInterPro annotationAdd BLAST150
Domaini428 – 581F5/8 type CInterPro annotationAdd BLAST154
Domaini635 – 805MAMInterPro annotationAdd BLAST171

Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like_sf.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
IPR035914. Sperma_CUB_dom_sf.
PANTHERiPTHR44185. PTHR44185. 1 hit.
PTHR44185:SF1. PTHR44185:SF1. 1 hit.
PfamiView protein in Pfam
PF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
PIRSFiPIRSF036960. Neuropilin. 1 hit.
SMARTiView protein in SMART
SM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS01180. CUB. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1W4YYY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCGLAVLLW TGILAAGAFK NDKCGEHIRI TNANYLTSPG YPVSYLPSQK
60 70 80 90 100
CVWVIQAPGP YQRILINFNP HFDLEDRECK YDYVEVRDGV DETGQLVGKY
110 120 130 140 150
CGKIAPSPIV SSGSQLYIKF VSDYETHGAG FSIRYEIFKT GPECSRNFTA
160 170 180 190 200
TSGVIKSPGF PEKYPNNLDC TFMIFAPKMS EIVLEFESFE LEPDTTPPTG
210 220 230 240 250
VFCRYDRLEI WDGFPGVGPY IGRFCGQNTP GRIISYTGIL ALTINTDNAI
260 270 280 290 300
AKEGFSANYT VIERTVPEDF DCKEPLGMES GEITSDQIIA SSQYNANWSP
310 320 330 340 350
ERSRLNYYEN GWTPAEDSSK EWIQVDLGFL RFVSGIGTQG AISQETKKSY
360 370 380 390 400
YVTSYKVDVS SSGEDWITLK EDSKQKIFQG NSNPTNVHIS DLPKPTLTRF
410 420 430 440 450
VRIRPVTWET GIALRFEVYG CKISEYPCSG MLGMVSGLIS DGQITASSHQ
460 470 480 490 500
DRNWMPENAR LLTSRSAWFL PPQAKPYTNE WLQVDLSQEK LLRGLIIQGG
510 520 530 540 550
KHRENKVFLR KFRLGYSNNG SDWKMVQDTN GSDRPKIFEG NQNYDTPELK
560 570 580 590 600
TLEPLLTRYL RVYPERGTAA GMGLRLELLG CEIQEPTSAP TTAPATTSVP
610 620 630 640 650
DECDDEQANC HSGTDGTTVA ETTTEVDTIP EYLWFACDFG WADSPSFCGW
660 670 680 690 700
TSEKDSTLRW QIQSSGTPTL NTGPNMDHTG GSGNFIYTLA TSSQESKAAR
710 720 730 740 750
LVSPVVTALD VDLCISFWYH MFGSHIGSLH VRQRKETAEG AADVLLWTVS
760 770 780 790 800
GHQGSRWREG RVLVPRSNKP YQVVIEAVVE SNILGDIAVD DIRILDNLNA
810 820 830 840 850
DDCKDPDVPT EPIQPEDIIV DITDFPDNEK TDDINGAGNM LKTLDPILIT
860 870 880 890 900
IIAMSALGVF LGAICGVVLY CACSHSAMSD RNLSALENYN FELVDGVKLK
910
KDKLNTQNCY SEA
Length:913
Mass (Da):101,443
Last modified:June 7, 2017 - v1
Checksum:i0CDF5E0FFA4ECCB6
GO

Sequence databases

RefSeqiXP_018596769.1. XM_018741253.1.

Genome annotation databases

GeneIDi108927750.

Similar proteinsi

Entry informationi

Entry nameiA0A1W4YYY8_9TELE
AccessioniPrimary (citable) accession number: A0A1W4YYY8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: December 20, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteomeImported