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Protein
Submitted name:

leucine-rich repeat serine/threonine-protein kinase 2 isoform X3

Gene

lrrk2

Organism
Scleropages formosus (Asian bonytongue)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
leucine-rich repeat serine/threonine-protein kinase 2 isoform X3Imported
Gene namesi
Name:lrrk2Imported
OrganismiScleropages formosus (Asian bonytongue)Imported
Taxonomic identifieri113540 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOsteoglossocephalaOsteoglossomorphaOsteoglossiformesOsteoglossidaeScleropages
Proteomesi
  • UP000192224 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini712 – 769ANK_REP_REGIONInterPro annotationAdd BLAST58
Domaini1317 – 1498RocInterPro annotationAdd BLAST182
Domaini1866 – 2129Protein kinaseInterPro annotationAdd BLAST264

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 32Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
1.25.40.20. 1 hit.
2.130.10.10. 1 hit.
3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032171. COR.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF16095. COR. 1 hit.
PF13855. LRR_8. 2 hits.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 8 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48403. SSF48403. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS51450. LRR. 13 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1W4YWF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDSHRGDTG DTEELRARLR KLTVRLRNMQ EGKQLDTLVQ ILLDLLDLAD
60 70 80 90 100
AHDSAPELFE DSEVLQPLMV VLSSYTDSPA VQQVGFSLLG RLVEICSATL
110 120 130 140 150
DQLSRPLCAG GDWDVLGIHQ QILKVLSVHA RHCGVILVVL KVLASLLKSD
160 170 180 190 200
VIVLLVLEDD MDVFDLLVHA MRCFHTSEEI LVHGCRCLQQ LLDQVPEEHL
210 220 230 240 250
LEFVNKQDHS VVLDAARVFH NSEEVLLQAL RVLLPLADPA GNVEMLMSGN
260 270 280 290 300
EKCYSIIKLA MESFPNNEPL QEVGCCLFQK FMSDSYYDIL VLNGVHRVIA
310 320 330 340 350
RACAEHEDNA KVQAAGLFCL AALTHTVFLS KELEEEQSAG KASQELSWEG
360 370 380 390 400
ICCRALEFHT ASAQVQEAAC LALNNLLLHN SQLHQMFGDV DGRTPIHRQV
410 420 430 440 450
MAVMLLHSSS RGVFQTAAST LGTLIDHNSK IRALLLSSGI HINVVEMMKK
460 470 480 490 500
HPSSPKVAES ACELLYKLFQ GRTASLDELA MAMCEILRVM KVHNLLPGVQ
510 520 530 540 550
FEALKASLTF LNPDRSLREH GASVGDPDTV DISLKVLKNQ CVLEGALTVC
560 570 580 590 600
LEALNRFIGM PHIQIWGLRV LCALADCSGA LELLCQQGAI DTTLHALLMF
610 620 630 640 650
PSEREVQLWG LSLLQCLVLK KEVSSTALPV LASLLVSSLR RYEMDTELLL
660 670 680 690 700
KGFQVAGKLL DSCAGSAAQL EREDFDRIIF EQLRAGLPER NPGPLQKLSC
710 720 730 740 750
SCLSQMAADS DIRYAMLEKA CMDGDVIMAE CLIQLGADVN RKTKTESLIY
760 770 780 790 800
QVCERGGPLE LVELLLASGI HEQNLRSTLS ASVHQQDGPV VSQLLGKLGL
810 820 830 840 850
DTNNNALCLG GFRLGHIEAS WLVPLVSERR ALSHRKRSSR GVSLARAILS
860 870 880 890 900
FQRRKSTFCS QRIPSDPSSL AYLSDESDEL SYISMDESIV FTSEDLESDG
910 920 930 940 950
SDETSYAKSK SQRDVFEDHN GQLVTLPKVQ QRRPSWEGSR ADSEPRFSRA
960 970 980 990 1000
ARSHGAPGGV ESLSLVGRAR EHIRLLDLSG NELDNLSCLT DEDLIRQHLE
1010 1020 1030 1040 1050
HIVRLDLSQN NLSEFPDLLC ENLRSLTRLD LHGNRLQSLP AGLLSLPSLS
1060 1070 1080 1090 1100
TLSLSQNCVG PLLMLPQGTR RPSLKQINLS FNHIAVFPSD VGHVLDRLEE
1110 1120 1130 1140 1150
LSLEGNKITE LCNVLCLPEM RLLDVSKNSI QHISPHFLCG CPKLETFSAS
1160 1170 1180 1190 1200
VNKLCHLSFL PSRIATLKLC DNHFTCIPEV VLQLPHLRSL DMRNNDIAFL
1210 1220 1230 1240 1250
PGPSAWTSVN LRELILSRNR ITTLDIRDPV EKWTRLEKLH LSENRLTEIP
1260 1270 1280 1290 1300
GSIGLLENLT SLDVSRNEGL CSFPDEMGML GRLWDLPLEG LQLNLDLKHI
1310 1320 1330 1340 1350
GSRTKDIVRF LQQRLKNATP YFRMKLIVVG NSGSGKTTLL RRLMKLKRAQ
1360 1370 1380 1390 1400
QHMELPTSGI DIKDWSIRDR EKRNIVLNVW DFSGGEEYKA SHHHFMTQRA
1410 1420 1430 1440 1450
LYLVVYDLSK GSGEVDALKP WLFNIKAMAP VSPVIVVGTH TDVSEEHHLQ
1460 1470 1480 1490 1500
ACMAKFKGEL VLHHSFATIR EHHMVNACEE SDSLRKLRRA ILREATSFKI
1510 1520 1530 1540 1550
QGQPVIGQRI PDSYLELERR LLLERSRGPP HFPVLLHQKL MDIVQEQQLQ
1560 1570 1580 1590 1600
LDETELAHAV HFLSEAGVLL HFDDPALQLR ELYFIKPQWL CSIISQILIL
1610 1620 1630 1640 1650
RSSGFSEHPK GIVQRSSVEK FLLESKCFPR HYLTQYLKLL EKFQIALPIC
1660 1670 1680 1690 1700
EDQLLIPSRL SDHRPVIELP HSENSEVIIR LYEMPYFPMG FWSRQLNRLL
1710 1720 1730 1740 1750
EISYTMLSGR EKGLRPNRIY WRTGIYLSWS PEAYCLVESA TMENTPESFI
1760 1770 1780 1790 1800
KITVPCSRKG RVLLAQVVDH IDSLLEEWFP GLLTTDVHGS GETLLKKWVL
1810 1820 1830 1840 1850
YSFEDGQQWN KMLLEELFTH INEDCLLVNP RNPKSTVHIS QIAPDLFLSD
1860 1870 1880 1890 1900
LPSTLMLNSE ELEIDFSKDY LLGHGGFGSV YRALYKNEEV AVKIFNKHAS
1910 1920 1930 1940 1950
KVHIHRLLRQ ELTVLGHLFH PSLVSLLAAS ICPPLLVMEL APRGSLDSLF
1960 1970 1980 1990 2000
ERENGSLNRK LQHRIALQVA DGLRYLHASM IVYRDLKPHN ILLFNLKMDS
2010 2020 2030 2040 2050
EIIAKITDYG IAQYCCSIGV RTSEGTPGFR APEVTRGNVI YNQQADVYSF
2060 2070 2080 2090 2100
GLLMYDLLTC GERISDGMKF PSEFDEMAVF GKLPDPVKHY GCSPWPHFED
2110 2120 2130 2140 2150
LMKQCMKENP QDRPTSSQVF DRLNSGEMLC LMREVAVCRT PNAECFAVAH
2160 2170 2180 2190 2200
GNDGPCICIG GGSSSQSRGC VTYVQLESGK LTTQEIDKSP VLCVATVRVS
2210 2220 2230 2240 2250
ESGSDWLGAG TQSGALIIIS PRDMLIQHCL QSVTDAVTSL YFHSHLQDSK
2260 2270 2280 2290 2300
KKSHLLVGTA DGVLVVYEDS EIQRDNGQPL KTLVIGNVNT PLMCLGQSSH
2310 2320 2330 2340 2350
SLDRTTVLAG CGTRVLSLTE DYDIWKSIET KSNNLHHGGQ AHLCEQGRGA
2360
HSGTVGQEKR END
Length:2,363
Mass (Da):264,266
Last modified:June 7, 2017 - v1
Checksum:i2DE46E068CDE64FF
GO

Sequence databases

RefSeqiXP_018595883.1. XM_018740367.1.
XP_018595884.1. XM_018740368.1.

Genome annotation databases

GeneIDi108927228.

Similar proteinsi

Entry informationi

Entry nameiA0A1W4YWF8_9TELE
AccessioniPrimary (citable) accession number: A0A1W4YWF8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: December 20, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported