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Protein

Kynureninase

Gene

kynU

Organism
Deinococcus hopiensis KR-140
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei77Pyridoxal phosphateUniRule annotation1
Binding sitei186Pyridoxal phosphateUniRule annotation1
Binding sitei189Pyridoxal phosphateUniRule annotation1
Binding sitei211Pyridoxal phosphateUniRule annotation1
Binding sitei240Pyridoxal phosphateUniRule annotation1
Binding sitei268Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
ORF Names:SAMN00790413_00814Imported
OrganismiDeinococcus hopiensis KR-140Imported
Taxonomic identifieri695939 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000192582 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei212N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 341Aminotran_5InterPro annotationAdd BLAST284

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1W1VAQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRDMFAIPP GIYMDGNSLG LMPHAAREAV LRRLDDWQRD AVGGWDAWFN
60 70 80 90 100
LAESLSPSMA RLVGARPHEV IATGSITANL HALLATLYRP EGPSSEKGRR
110 120 130 140 150
HLVATSLDFP SDVYALQSWA EREGAEVRLI PSRDGHTLHA DDILTALADD
160 170 180 190 200
VAVAVLPTVL YRSGQLLDVE GLTRAAHERG VLIGWDAAHS VGSVPHALHD
210 220 230 240 250
AGADFAVWCH YKYVNAGPGA PGGLFLHERH HGQAPGLRGW WGHAKDTQFE
260 270 280 290 300
MAHHFRPAAG AGAYQLGTPP ILALAGLEGA LAVFDSVTME EVRARSLELT
310 320 330 340 350
SRLMALAEAH LPEMQVVTPH DPACRGGHVA LAHPEAQALS VALRARGIVP
360 370 380 390
DFRQPDILRL APVALYNTEA EVEETVGALR ELLRTGAHRE VGAAGLVT
Length:398
Mass (Da):42,853
Last modified:June 7, 2017 - v1
Checksum:i9F276F7AA815E76F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FWWU01000009 Genomic DNA Translation: SMB90557.1

Similar proteinsi

Entry informationi

Entry nameiA0A1W1VAQ5_9DEIO
AccessioniPrimary (citable) accession number: A0A1W1VAQ5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: March 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health