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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Nocardia donostiensis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD), Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydrataseUniRule annotationSAAS annotation (EC:4.2.1.19UniRule annotationSAAS annotation)
Short name:
IGPDUniRule annotation
Gene namesi
Name:hisBUniRule annotation
ORF Names:B0T46_20550Imported
OrganismiNocardia donostiensisImported
Taxonomic identifieri1538463 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000188836 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd07914. IGPD. 1 hit.
HAMAPiMF_00076. HisB. 1 hit.
InterProiView protein in InterPro
IPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
PANTHERiPTHR23133. PTHR23133. 1 hit.
PfamiView protein in Pfam
PF00475. IGPD. 1 hit.
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiView protein in PROSITE
PS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1W0B9D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTEASMNR TARVERTTRE SSIVVELDLD GTGRTDISTG VPFYDHMLTA
60 70 80 90 100
LGAHASFDLT VRAEGDIEIE AHHTVEDTAI VFGQALGQAL GDKKGIRRFG
110 120 130 140 150
DAYIPMDETL AHAAVDVSGR PYCVHTGEPE HLLHAVIPGS PVPSRGRPGA
160 170 180 190 200
PYSTVLNRHV FESIALNARI ALHVRVLYGR DQHHVTEAEF KAVARALRAA
210
VEPDPRVSGV PSTKGAL
Length:217
Mass (Da):23,417
Last modified:June 7, 2017 - v1
Checksum:iDD2559DFC8808319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MUMY01000019 Genomic DNA. Translation: ONM46873.1.
RefSeqiWP_077119895.1. NZ_MUMY01000019.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1W0B9D7_9NOCA
AccessioniPrimary (citable) accession number: A0A1W0B9D7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: September 27, 2017
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported