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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Betaproteobacteria bacterium ADurb.Bin341
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPurine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationSAAS annotation (EC:6.3.3.1UniRule annotationSAAS annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotationImported
ORF Names:BWY57_01601Imported
OrganismiBetaproteobacteria bacterium ADurb.Bin341Imported
Taxonomic identifieri1852821 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteria

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 164AIRSInterPro annotationAdd BLAST101
Domaini177 – 340AIRS_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1V5QSS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKPSLSYR DAGVDIDAGD ALVDRIKPLA KKTLRDGVLG GIGGFGALFE
60 70 80 90 100
VPKRYREPVL VSGTDGVGTK LRLAFQLNRH DTVGQDLVAM SVNDILVQGA
110 120 130 140 150
ESLFFLDYFA CGKLDVDTAA SVIGGVARGC ELAGCALIGG ETAEMPGMYP
160 170 180 190 200
EGEYDLAGFA VGVVEKSKII TGSTIDAGDV VIGLASSGAH SNGYSLVRKI
210 220 230 240 250
IGRAQPDMNA RFDGDRTLAD VVMAPTRIYV KPMLALMQKI TVKGMAHITG
260 270 280 290 300
GGLLENVPRV LPENVTAELH KAAWPRPKLF DWLQAEGQVA ENEMHRVFNC
310 320 330 340
GIGMVVIVSA AEAEIALAEL RAAGETAYRI GMIRARQAGE AQTIVQ
Length:346
Mass (Da):36,700
Last modified:June 7, 2017 - v1
Checksum:iF5FEBD47127F1742
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MWBA01000069 Genomic DNA. Translation: OQA32916.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1V5QSS4_9PROT
AccessioniPrimary (citable) accession number: A0A1V5QSS4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: March 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported