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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacillus sp. LEMMY01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:B1A75_07400Imported
OrganismiGeobacillus sp. LEMMY01Imported
Taxonomic identifieri1954237 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000191301 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 170tRNA-synt_1gInterPro annotationAdd BLAST133
Domaini219 – 399tRNA-synt_1_2InterPro annotationAdd BLAST181
Domaini412 – 604tRNA-synt_1InterPro annotationAdd BLAST193
Domaini655 – 768Anticodon_1InterPro annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili767 – 787Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi576 – 580"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 2 hits.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1V4PAA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNHREIEK KWQDYWEKNK TFRTPDDDDK PKFYVLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT
110 120 130 140 150
QKNIDNFRRQ IKSLGFSYDW DREINTTDPN YYKWTQWIFL KLYEKGLAYM
160 170 180 190 200
DEVPVNWCPA LGTVLANEEV INGRSERGGH PVIRKPMRQW MLRITAYADR
210 220 230 240 250
LLEDLEELDW PESIKEMQRN WIGRSEGAEI EFAVDGHDET FTVFTTRPDT
260 270 280 290 300
LFGATYTVLA PEHPLVEKIT TPEQKPAVDA YLKEIQSKSD LERTDLAKEK
310 320 330 340 350
TGVFTGAYAI HPVTGDRLPI WIADYVLMSY GTGAIMAVPA HDERDYEFAK
360 370 380 390 400
KFHLPMKEVV AGGNIEKEAY TGDGEHINSE FLNGLNKQEA IEKMIAWLEE
410 420 430 440 450
HGKGRKKVSY RLRDWLFSRQ RYWGEPIPII HWEDGTMTPV PEEELPLVLP
460 470 480 490 500
KTDEIRPSGT GESPLANIEE WVNVVDPKTG KKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPHNDK QLADPEKLKK WLPVDVYIGG AEHAVLHLLY ARFWHKFLYD
560 570 580 590 600
LGIVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI IESHGADTLR
610 620 630 640 650
LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVTENGE LNPNIVDEPA
660 670 680 690 700
NDTLERVYHQ TVKKVTEDYE ALRFNTAISQ LMVFINEAYK AEQMKKEYME
710 720 730 740 750
GFVKLLSPVC PHIGEELWQK LGHTDTIAYE PWPTYDETKL VEDVVEIVVQ
760 770 780 790 800
INGKVRSRLH VPVDLPKEAL EERALADEKI KEQLEGKTVR KVIAVPGKLV

NIVAN
Length:805
Mass (Da):92,837
Last modified:June 7, 2017 - v1
Checksum:i76C883EE6BEEBBCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MVKA01000011 Genomic DNA. Translation: OPX03655.1.
RefSeqiWP_074044106.1. NZ_MVKA01000011.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1V4PAA8_9BACI
AccessioniPrimary (citable) accession number: A0A1V4PAA8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: March 28, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported