deaD

Functionⁱ

DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.UniRule annotation

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.UniRule annotation

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
ATP-dependent RNA helicase activity Source: UniProtKB-UniRule
RNA binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to cold Source: InterPro
ribosomal large subunit assembly Source: UniProtKB-UniRule
RNA catabolic process Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	HelicaseUniRule annotationImported, Hydrolase, RNA-bindingUniRule annotation
Biological process	Stress responseUniRule annotation
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-dependent RNA helicase DeaDUniRule annotation (EC:3.6.4.13UniRule annotation) Alternative name(s): Cold-shock DEAD box protein AUniRule annotation
Gene namesⁱ	Name:deaDUniRule annotation ORF Names:BV935_04455Imported
Organismⁱ	Haemophilus influenzaeImported
Taxonomic identifierⁱ	727 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus
Proteomesⁱ	UP000189053 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00964

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	5 – 33	Q_MOTIFInterPro annotationAdd BLAST	29
Domainⁱ	36 – 207	Helicase ATP-bindingInterPro annotationAdd BLAST	172
Domainⁱ	231 – 378	Helicase C-terminalInterPro annotationAdd BLAST	148

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	5 – 33	Q motifPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DeaD subfamily.UniRule annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079. HELICc. 1 hit. cd12499. RRM_EcCsdA_like. 1 hit.
Gene3Dⁱ	3.30.70.330. 1 hit.
HAMAPⁱ	MF_00964. DEAD_helicase_DeaD. 1 hit.
InterProⁱ	View protein in InterPro IPR034415. CsdA_RRM. IPR005580. DbpA/CsdA_RNA-bd_dom. IPR011545. DEAD/DEAH_box_helicase_dom. IPR028618. DEAD_helicase_DeaD. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR012677. Nucleotide-bd_a/b_plait_sf. IPR027417. P-loop_NTPase. IPR000629. RNA-helicase_DEAD-box_CS. IPR014014. RNA_helicase_DEAD_Q_motif.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03880. DbpA. 1 hit. PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit.
SMARTⁱ	View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00039. DEAD_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51195. Q_MOTIF. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A1V2BWN1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTDKITFNDL GLPEFILKAV SDLGFETPSP IQQACIPHLL SGNDVLGMAQ 
        60         70         80         90        100
TGSGKTAAFA LPLLAQIDPS EKHPQMLVMA PTRELAIQVA DACEQFVKYA 
       110        120        130        140        150
HGTRIVTLYG GQRYDIQLRA LKQGAQVVVG TPGRILDHIR RGTLNLSELR 
       160        170        180        190        200
FIVLDEADEM LRMGFIDDVE TVMAELPENH QTALFSATMP EPIRRITKRF 
       210        220        230        240        250
MNDPKEVKIK VNNENAPDIE QSCWYVHGVR KNEALLRFLE VEDFDAAIIF 
       260        270        280        290        300
ARTKTGTLDI TELLEKNGFR SAALNGDMTQ QLREQTLDRL RNGSLDIVVA 
       310        320        330        340        350
TDVAARGIDI ERISLVVNYD IPLDAESYVH RIGRTGRAGR SGRALLFVEP 
       360        370        380        390        400
RERRLLRNIE HLMKKGINEV ELPNHLVLQE CRRKKFVAKI TKQLEHHDLE 
       410        420        430        440        450
QYRSLLEDLF TADQDQEDIA AAMLMLLQGK QKLILPPDPS MEKRRRERNE 
       460        470        480        490        500
CGDRRENPRS AERRGERKGY GNPRPMDLYR IEVGRADGVE VRHIVGAIAN 
       510        520        530        540        550
EGDINSRYIG HIKLYDDYTT VELPQGMPKE LLQQFGKTRV LNKQMQMSFL 
       560        570        580        590        600
GAVKSDNSRG GDDFNGKRKG RGGDFRGERG RNERNGDNRG NRKFNEKSNR 
       610 
TFSDKPRRDR RSSF

Length:614

Mass (Da):69,751

Last modified:June 7, 2017 - v1

Checksum:ⁱFE4ED959C690565D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	MTBH01000019 Genomic DNA. Translation: OMP98642.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_050948859.1. NZ_MTBH01000019.1.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A1V2BWN1	P44586 A0A158SZY7 UPI00014FC05B A4N4N5 A0A0Y7L785 UPI0006812356 A0A0Y0EP04 E1X9H6 A0A2J1DLU6 Q19V40 +71	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Haemophilus influenzae Haemophilus influenzae R3021 Streptococcus pneumoniae Haemophilus influenzae (strain 10810) Haemophilus influenzae NT127 Haemophilus influenzae (strain PittGG) Haemophilus influenzae 22.1-21 Haemophilus influenzae PittII Haemophilus influenzae 22.4-21 And more	613	UniRef90_P44586	Cluster: ATP-dependent RNA helicase DeaD	82

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A1V2BWN1	P44586 A0A158SZY7 UPI00014FC05B UPI0006812356 A4N4N5 A0A0Y7L785 E7A839 UPI000664D473 UPI0008A8F934 UPI00068068D2 +708	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Haemophilus influenzae Haemophilus influenzae R3021 Haemophilus influenzae F3031 Haemophilus sp. HMSC071C11 Haemophilus aegyptius ATCC 11116 Haemophilus Haemophilus influenzae (strain 86-028NP) Haemophilus influenzae (strain NTHi 3655) Haemophilus aegyptius And more	613	UniRef50_P44586	Cluster: ATP-dependent RNA helicase DeaD	719

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	MTBH01000019 Genomic DNA. Translation: OMP98642.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_050948859.1. NZ_MTBH01000019.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079. HELICc. 1 hit. cd12499. RRM_EcCsdA_like. 1 hit.
Gene3Dⁱ	3.30.70.330. 1 hit.
HAMAPⁱ	MF_00964. DEAD_helicase_DeaD. 1 hit.
InterProⁱ	View protein in InterPro IPR034415. CsdA_RRM. IPR005580. DbpA/CsdA_RNA-bd_dom. IPR011545. DEAD/DEAH_box_helicase_dom. IPR028618. DEAD_helicase_DeaD. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR012677. Nucleotide-bd_a/b_plait_sf. IPR027417. P-loop_NTPase. IPR000629. RNA-helicase_DEAD-box_CS. IPR014014. RNA_helicase_DEAD_Q_motif.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03880. DbpA. 1 hit. PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit.
SMARTⁱ	View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00039. DEAD_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51195. Q_MOTIF. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A1V2BWN1_HAEIF
Accessionⁱ	A0A1V2BWN1Primary (citable) accession number: A0A1V2BWN1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 7, 2017
	Last sequence update:	June 7, 2017
	Last modified:	March 28, 2018
	This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - A0A1V2BWN1 (A0A1V2BWN1_HAEIF)

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ATP-dependent RNA helicase DeaD

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Family & Domainsⁱ

Domains and Repeats

Motif

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A1V2BWN1 (A0A1V2BWN1_HAEIF)

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ATP-dependent RNA helicase DeaD

deaD

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ