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Protein

Outer capsid protein VP4

Gene
N/A
Organism
Rotavirus A
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Outer capsid protein VP5*: Forms the spike "foot" and "body" and acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. During entry, the part of VP5* that protrudes from the virus folds back on itself and reorganizes from a local dimer to a trimer. This reorganization may be linked to membrane penetration by exposing VP5* hydrophobic region. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.SAAS annotation

GO - Biological processi

Keywordsi

Molecular functionHemagglutininSAAS annotation
Biological processHost-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Viral penetration via permeabilization of host membraneSAAS annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid protein VP4UniRule annotationSAAS annotation
OrganismiRotavirus AImported
Taxonomic identifieri28875 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Proteomesi
  • UP000226006 Componenti: Genome

Subcellular locationi

  • Host cell membrane SAAS annotation
  • host cytoskeleton SAAS annotation
  • Host endoplasmic reticulum-Golgi intermediate compartment SAAS annotation
  • Host rough endoplasmic reticulum SAAS annotation
  • Virion UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host cell membraneSAAS annotation, Host cytoplasm, Host cytoskeletonSAAS annotation, Host endoplasmic reticulumSAAS annotation, Host membrane, Membrane, Outer capsid proteinSAAS annotation, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 224VP4_haemagglutInterPro annotationAdd BLAST160
Domaini250 – 474Rota_VP4_MIDInterPro annotationAdd BLAST225
Domaini485 – 776VP4_helicalInterPro annotationAdd BLAST292

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili491 – 511Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the rotavirus VP4 family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR035330 Rota_VP4_MID
IPR038017 Rota_VP4_MID_sf
IPR000416 VP4_concanavalin-like
IPR035329 VP4_helical
PfamiView protein in Pfam
PF17477 Rota_VP4_MID, 1 hit
PF00426 VP4_haemagglut, 1 hit
PF17478 VP4_helical, 1 hit
SUPFAMiSSF111379 SSF111379, 1 hit
SSF49899 SSF49899, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1V0FUK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLIYRQLL TNSYSVDLSD EIQKIGSTKT QNVTVNPGPF AQTGYAPVNW
60 70 80 90 100
GPGEINDSTT VEPVLDGPYQ PTTFNPPVDY WMLLAPTIAG VVVEGTNNTD
110 120 130 140 150
RWLATILVEP NVTSEVRSYT LFGVQEQITI ANTSQTQWKF IDVVKTTQNG
160 170 180 190 200
SYSQYGPLQS SPKLYAVMKH NGKIYTYNGE TPNATTGYCS TTNYDSVNMT
210 220 230 240 250
AFCDFYIIPR AEESTCTEYI NNGLPPIQNT RNIVPLALSA RKIISHRAQA
260 270 280 290 300
NEDIVVSETS LWKEMQYNRD ITIRFKFANS IVKSGGLGYK WSEISFKPAN
310 320 330 340 350
YQYTYIRDGE EVTAHTTCSV NGVNDFSFNG GSLPTDFVIS RYEVIKENSY
360 370 380 390 400
VYVDYWDDSQ AFRNMVYVRS LAANLNSVMC TDGDYSFALP VGQWPVMNGG
410 420 430 440 450
AVSLHSAGVT LSTEFTDFVS LNSLRFRFRL ADEEPSFSIT RTSVSSLYGL
460 470 480 490 500
PAANPNNGKE YYEIAGRFSL ISLVPSNDDY QTPIANSVTV RQDLERQLGE
510 520 530 540 550
LRGEFNALSQ EIAMSQLIDL ALLPLDMFSM FSGIKSTIDA AKSMATSVMK
560 570 580 590 600
KFKKSGLASS VSTLTDSLSD AASSVSRSSS IRSVGSSASA WTDVSNQITD
610 620 630 640 650
ETSSVSTIST QTSTISRSLR LKEIATQTEG MNFDDISAAV LKTKIDRSTE
660 670 680 690 700
ISPNTLPDII SEASEKFIPN RAYRVINNNE VLEAGTDGRF FAYRVDTFEE
710 720 730 740 750
IPFDVQKFAD LVTDSPVISA IIDFKTLKNL NDNYGITRKQ ALNLLSSDPR
760 770
VLREFINQDN PIIRNRIEQL IMQSRL
Length:776
Mass (Da):86,082
Last modified:June 7, 2017 - v1
Checksum:i8DFF08581210A8E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KX814943 Genomic RNA Translation: ARB49195.1

Similar proteinsi

Entry informationi

Entry nameiA0A1V0FUK0_9REOV
AccessioniPrimary (citable) accession number: A0A1V0FUK0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: June 20, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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