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Protein
Submitted name:

disintegrin and metalloproteinase domain-containing protein 22 isoform X1

Gene

Adam22

Organism
Mesocricetus auratus (Golden hamster)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinImported

Names & Taxonomyi

Protein namesi
Submitted name:
disintegrin and metalloproteinase domain-containing protein 22 isoform X1Imported
Gene namesi
Name:Adam22Imported
OrganismiMesocricetus auratus (Golden hamster)Imported
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei735 – 758HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501055496824 – 980Sequence analysisAdd BLAST957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi501 ↔ 521PROSITE-ProRule annotation
Disulfide bondi700 ↔ 709PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini237 – 436Peptidase M12BInterPro annotationAdd BLAST200
Domaini442 – 529DisintegrinInterPro annotationAdd BLAST88
Domaini673 – 710EGF-likeInterPro annotationAdd BLAST38

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR024079. MetalloPept_cat_dom_sf.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF07974. EGF_2. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1U8CU29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAAAAASFW LLCVVGTCPL VRCGPAGDAS LRELERADEN RFLERQSIVP
60 70 80 90 100
LRLIYRLGGE DETWHDRLNT RVRGDLGGQQ LTHVDKTSFQ VDAFGTSFIL
110 120 130 140 150
DVRLNHELLS SGYVERHIER GGKAVENKGG EHCYYQGQIR GNPVSFVALS
160 170 180 190 200
TCHGLHGMFY DGNHTYLIEP EENETSQGES RFHSVYRSRR FEFPLDDLPT
210 220 230 240 250
EFQRVNVTPP QFILKPRLKR SKRQLLRFPR NVEEETKYIE LMIVNDHIMF
260 270 280 290 300
KKHRLSVVHT NTYAKSVVNM ADMIYKDQLK TRIVLVAMET WAADNKFAIS
310 320 330 340 350
ENPLITLREF MKYRRDFIKE KSDAVHLFSG SQFESSRSGA AYIGGICSLL
360 370 380 390 400
RGGGVNEFGK TDLMAVTLAQ SLAHNIGIIS DKRKLASGEC KCEDTWSGCV
410 420 430 440 450
MGDTGYYLPK KFTQCNIEEY HDFLNSGGGA CLFNKPSKLL DPPECGNGFI
460 470 480 490 500
ETGEECDCGT TAECALEGAE CCKKCTLTQD SQCSDGLCCK KCKFQPLGTV
510 520 530 540 550
CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC FGGRCKTRDR
560 570 580 590 600
QCKYIWGQKV TASDKYCYEK LNIEGTEKGN CGKDKDTWIQ CSKRDVLCGY
610 620 630 640 650
LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGGHVKL EEDVDLGYVE
660 670 680 690 700
DGTPCGPQMM CLEHRCLSVA SFNFSTCLSS KAGTVCSGNG VCSNELKCVC
710 720 730 740 750
NRHWVGADCS IHFPHNDDAK AGITLSGNGV AGTNIIIGII AGTILVLALI
760 770 780 790 800
LGITAWGYKN YREQRQLPQG DYVKKPGDGD SFYSDIPPGV STNSASSSKK
810 820 830 840 850
RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNLGGN KKKIRGKRFR
860 870 880 890 900
PRSNSTEREP QAPEPGHSLA QTILSQGISP GGSDSPQTGS LDHRYLNPWF
910 920 930 940 950
KRDYNVAKWV EDVNRNTEGP YFSSQDGQHQ EDRTLSPAKS PSSSTGSIAS
960 970 980
SRKYPYPMPP LPDEEKTVNR QSARLWETSI
Length:980
Mass (Da):108,678
Last modified:May 10, 2017 - v1
Checksum:i4DE9B44A495F060B
GO

Sequence databases

RefSeqiXP_012978944.1. XM_013123490.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1U8CU29_MESAU
AccessioniPrimary (citable) accession number: A0A1U8CU29
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: December 20, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported