PFKFB4

Functionⁱ

GO - Molecular functionⁱ

6-phosphofructo-2-kinase activity Source: InterPro
ATP binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fructose 2,6-bisphosphate metabolic process Source: InterPro
fructose metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	KinaseImported, Transferase

Molecular function

KinaseImported, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1Imported
Gene namesⁱ	Name:PFKFB4Imported
Organismⁱ	Tarsius syrichta (Philippine tarsier)Imported
Taxonomic identifierⁱ	1868482 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Tarsiiformes › Tarsiidae › Carlito
Proteomesⁱ	UP000189704 Componentⁱ: Genome assembly

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 249	6PF2KInterPro annotationAdd BLAST		215

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07067. HP_PGM_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
InterProⁱ	View protein in InterPro IPR003094. 6Pfruct_kin. IPR013079. 6Phosfructo_kin. IPR013078. His_Pase_superF_clade-1. IPR029033. His_PPase_superfam. IPR027417. P-loop_NTPase. IPR001345. PG/BPGM_mutase_AS.
PANTHERⁱ	PTHR10606. PTHR10606. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01591. 6PF2K. 1 hit. PF00300. His_Phos_1. 1 hit.
PRINTSⁱ	PR00991. 6PFRUCTKNASE.
SMARTⁱ	View protein in SMART SM00855. PGAM. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit. SSF53254. SSF53254. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00175. PG_MUTASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A1U7TF24-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASPRELTQN PLKKIWMPYS NGRPALHACP RGVCMTNCPT LIVMVGLPAR 
        60         70         80         90        100
GKTYISKKLT RYLNWIGVPT REFNVGQYRR DMVKTYKSFE FFLPDNEEGL 
       110        120        130        140        150
KIRKKCALAA LCDVRRFLSE EGGHVAVFDA TNTTRERRAT IFNFGEQNGY 
       160        170        180        190        200
KTFFVESICV DPEVIAANIV QVKLGSPDYV NRDSDEATED FMRRIECYEN 
       210        220        230        240        250
SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY YLMNIHVTPR 
       260        270        280        290        300
SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW 
       310        320        330        340        350
TSQMKRTIQT AEALGVPYEQ WKVLNEIDAG VCEEMTYEEI QDHYPLEFAL 
       360        370        380        390        400
RDQDKYRYRY PKGESYEDLV QRLEPVIMEL ERQENVLVIC HQAVMRCLLA 
       410        420        430        440        450
YFLDKAAEQL PYLKCPLHTV LKLTPVAYGC KVESIFLNVA AVNTHRDRPQ 
       460 
NVDISRPPEE ALVTVPAHQ

Length:469

Mass (Da):54,011

Last modified:May 10, 2017 - v1

Checksum:ⁱE99F81F6314CE450

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_008056450.1. XM_008058259.1.

RefSeqⁱ

XP_008056450.1. XM_008058259.1.

Genome annotation databases

Ensemblⁱ	ENSTSYT00000037074; ENSTSYP00000030024; ENSTSYG00000008225.
GeneIDⁱ	103260622.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A1U7TF24	P25114 F7FKL9 UPI0003D0A6C8 E2RND7 UPI00004BD6DC UPI0003AD8F5F UPI000C9F27AA UPI0004F09124 UPI000CA05903 UPI000819F59B +220	Rattus norvegicus (Rat) Canis lupus familiaris (Dog) (Canis familiaris) Octodon degus (Degu) (Sciurus degus) Pan paniscus (Pygmy chimpanzee) (Bonobo) Trichechus manatus latirostris (Florida manatee) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Equus caballus (Horse) Equus asinus (Donkey) (Equus africanus asinus) And more	469	UniRef90_P25114	Cluster: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4	231

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A1U7TF24	Q9JJH5 Q9JJ77 UPI00077DEF3A UPI0004ED27FB UPI00022F3AA7 UPI000B4F04AE A0A1U7QVD0 UPI000A31A049 A0A286X9Q0 A0A087WRM7 +1513	Rattus norvegicus (Rat) Peromyscus maniculatus bairdii (Prairie deer mouse) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Mesocricetus auratus (Golden hamster) Mus caroli (Ryukyu mouse) (Ricefield mouse) Cavia porcellus (Guinea pig) Mus musculus (Mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) And more	557	UniRef50_Q9JJH5	Cluster: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	1,524

Cross-referencesⁱ

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_008056450.1. XM_008058259.1.

RefSeqⁱ

XP_008056450.1. XM_008058259.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSTSYT00000037074; ENSTSYP00000030024; ENSTSYG00000008225.
GeneIDⁱ	103260622.

Organism-specific databases

CTDⁱ	5210.

CTDⁱ

5210.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07067. HP_PGM_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
InterProⁱ	View protein in InterPro IPR003094. 6Pfruct_kin. IPR013079. 6Phosfructo_kin. IPR013078. His_Pase_superF_clade-1. IPR029033. His_PPase_superfam. IPR027417. P-loop_NTPase. IPR001345. PG/BPGM_mutase_AS.
PANTHERⁱ	PTHR10606. PTHR10606. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01591. 6PF2K. 1 hit. PF00300. His_Phos_1. 1 hit.
PRINTSⁱ	PR00991. 6PFRUCTKNASE.
SMARTⁱ	View protein in SMART SM00855. PGAM. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit. SSF53254. SSF53254. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00175. PG_MUTASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A1U7TF24_TARSY
Accessionⁱ	A0A1U7TF24Primary (citable) accession number: A0A1U7TF24
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2017
	Last sequence update:	May 10, 2017
	Last modified:	February 28, 2018
	This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A0A1U7TF24 (A0A1U7TF24_TARSY)

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6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Family & Domainsⁱ

Domains and Repeats

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A1U7TF24 (A0A1U7TF24_TARSY)

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6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1

PFKFB4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ