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Protein
Submitted name:

glutamate receptor ionotropic, NMDA 2B

Gene

GRIN2B

Organism
Alligator sinensis (Chinese alligator)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
glutamate receptor ionotropic, NMDA 2BImported
Gene namesi
Name:GRIN2BImported
OrganismiAlligator sinensis (Chinese alligator)Imported
Taxonomic identifieri38654 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator
Proteomesi
  • UP000189705 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei560 – 582HelicalSequence analysisAdd BLAST23
Transmembranei603 – 620HelicalSequence analysisAdd BLAST18
Transmembranei632 – 657HelicalSequence analysisAdd BLAST26
Transmembranei823 – 846HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501053278429 – 1501Sequence analysisAdd BLAST1473

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 801PBPeInterPro annotationAdd BLAST369
Domaini442 – 505Lig_chan-Glu_bdInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PRINTSiPR00177. NMDARECEPTOR.
SMARTiView protein in SMART
SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1U7RQM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRAECYSP QFWLVLAVLA TTGGGARAQK SHPSIGVAVI LVGTSDEVAI
60 70 80 90 100
KDAHEKDDFH HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA
110 120 130 140 150
DDTDQEAIAQ ILDFISAQTL TPILGIHGGS SMIMADKDES SMFFQFGPSI
160 170 180 190 200
EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ DFVNKIRSTI EHSFVGWELE
210 220 230 240 250
EVLLLDMSLD DGDSKIQNQL KKLQSPVILL YCTKEEATYI FEVANSVGLT
260 270 280 290 300
GYGYTWIVPS LVAGDTDTVP SEFPTGLISV SYDEWDYGLP ARVRDGIAII
310 320 330 340 350
TTAASDMLSE HSFIPEPKSS CYNTQEKRIY QSNMLNRYLI NVTFEGRNLS
360 370 380 390 400
FSEDGYQMHP KLVIILLTKE RKWERVGKWK DKNLQMKYYV WPRFELYPDS
410 420 430 440 450
EEREDDHLSI VTLEEAPFVI VENVDPLSGT CMRNTVPCQK RVVSENKTDE
460 470 480 490 500
EPDYMKKCCK GFCIDILKKI SKSVKFTYDL YLVTNGKHGK KINGTWNGMI
510 520 530 540 550
GEVVTKRAYM AVGSLTINEE RSEVVDFSVP FIETGISVMV SRSNGTVSPS
560 570 580 590 600
AFLEPFSADV WVMMFVMLLI ISAVAVFVFE YFSPVGYNRC LADGREPGGP
610 620 630 640 650
SFTIGKAIWL LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF AVIFLASYTA
660 670 680 690 700
NLAAFMIQEE YVDQVSGLSD KKFQKPNDFS PPFRFGTVPN GSTERNIRNN
710 720 730 740 750
YPEMHSYMVK FNQRGVGDAL LSLKTGKLDA FIYDAAVLNY MAGRDEGCKL
760 770 780 790 800
VTIGSGKVFA STGYGIAIQK DSGWKRQVDL AILQLFGDGE MEELEALWLT
810 820 830 840 850
GICHNEKNEV MSSQLDIDNM AGVFYMLGAA MALSLITFIC EHLFYWQFRH
860 870 880 890 900
CFMGVCSGKP GMVFSISRGI YSCIHGVAIE ERQSAMNSPT ATMNNTHSNI
910 920 930 940 950
LRLLRTAKNM ANLSGVNGSP QSALDFIRRE SSVYDISEHR RSFTHSDCKS
960 970 980 990 1000
YNNPPCEENL FSDYISEVER TFGNLQLKDS NVYQDHYHHH HRPHSIGSAS
1010 1020 1030 1040 1050
SIDGLYDCDN PPFSAQPRSI SKKPLDLGLP SSKHSQLGDL YGKFSFKSDR
1060 1070 1080 1090 1100
YSGGGGHDDL IRSDVSDIST HTVTYGNIEG NAAKRRKQQY KDSLKKRPAS
1110 1120 1130 1140 1150
AKSRREFDEI ELAYRRRPPR SPDHKRYFRD KEGLRDFYLD QFRAKENSPH
1160 1170 1180 1190 1200
WEHVDLTDIY KERGDEFKRD AVGGGGACTN RAHHKHGSGE FGSANEHKHG
1210 1220 1230 1240 1250
VVSGVPAPWE KNLTNLDWED RTGANFCRSC PSKLHNYTPT VVGQNSTRQP
1260 1270 1280 1290 1300
CIRCEACKKA GNLYDISEDN SLQELDQPPA PVPVPTSTSS SSKYPQSPSN
1310 1320 1330 1340 1350
SASKVQKKNR NKLRRQHSYD TFVDLQKEES ALAPRSVSLK DKGRFLEGSP
1360 1370 1380 1390 1400
YAHMFEMPAN ETTFANNKSS VPATSYHHHN NPGGSGYMLS KSLYPDRVTQ
1410 1420 1430 1440 1450
NPFIPTFGDD QCLLHGSKSY FFRQPVVAGG PKARPDFRAI VTTNKPVVSA
1460 1470 1480 1490 1500
LHGAVPARFQ KDICIGNQSN PCVPNNKNPR AFNGSSNGHV YEKLSSIESD

V
Length:1,501
Mass (Da):168,203
Last modified:May 10, 2017 - v1
Checksum:i31A212DA1CAE70DE
GO

Sequence databases

RefSeqiXP_006024221.1. XM_006024159.1.

Genome annotation databases

GeneIDi102380409.

Similar proteinsi

Entry informationi

Entry nameiA0A1U7RQM8_ALLSI
AccessioniPrimary (citable) accession number: A0A1U7RQM8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported