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Protein

Voltage-dependent T-type calcium channel subunit alpha

Gene

Cacna1i

Organism
Mesocricetus auratus (Golden hamster)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1iImported
OrganismiMesocricetus auratus (Golden hamster)Imported
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei206 – 230HelicalSequence analysisAdd BLAST25
Transmembranei343 – 364HelicalSequence analysisAdd BLAST22
Transmembranei370 – 395HelicalSequence analysisAdd BLAST26
Transmembranei720 – 742HelicalSequence analysisAdd BLAST23
Transmembranei762 – 778HelicalSequence analysisAdd BLAST17
Transmembranei798 – 820HelicalSequence analysisAdd BLAST23
Transmembranei1130 – 1148HelicalSequence analysisAdd BLAST19
Transmembranei1168 – 1189HelicalSequence analysisAdd BLAST22
Transmembranei1201 – 1227HelicalSequence analysisAdd BLAST27
Transmembranei1265 – 1287HelicalSequence analysisAdd BLAST23
Transmembranei1366 – 1390HelicalSequence analysisAdd BLAST25
Transmembranei1446 – 1463HelicalSequence analysisAdd BLAST18
Transmembranei1483 – 1502HelicalSequence analysisAdd BLAST20
Transmembranei1581 – 1600HelicalSequence analysisAdd BLAST20
Transmembranei1667 – 1689HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 406Ion_transInterPro annotationAdd BLAST331
Domaini598 – 825Ion_transInterPro annotationAdd BLAST228
Domaini1128 – 1400Ion_transInterPro annotationAdd BLAST273
Domaini1446 – 1699Ion_transInterPro annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1399 – 1426Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR030162. CACNA1I.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR002077. VDCCAlpha1.
PANTHERiPTHR10037:SF209. PTHR10037:SF209. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 4 hits.
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

A0A1U7QGG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSILPPPS AAAQASEPGI TEQPGSQSPP PSPPGLEEPL DGANPDIPHP
60 70 80 90 100
DLAPVAFFCL RQTTSPRNWC IKMVCNPWFE CVSMLVILLN CVTLGMYQPC
110 120 130 140 150
DDMECLSDRC KILQVFDDFI FIFFAMEMVL KMVALGIFGK KCYLGDTWNR
160 170 180 190 200
LDFFIVMAGM VEYSLDLQNI NLSAIRTVRV LRPLKAINRV PSMRILVNLL
210 220 230 240 250
LDTLPMLGNV LLLCFFVFFI FGIIGVQLWA GLLRNRCFLE ENFTVQGDVA
260 270 280 290 300
LPPYYQPEED DEMPFICSLS GDNGIMGCHE IPPLKEQGRE CCLSKDDVYD
310 320 330 340 350
FGAGRQDLNA SGLCVNWNRY YNVCRTGNAN PHKGAINFDN IGYAWIVIFQ
360 370 380 390 400
VITLEGWVEI MYYVMDAHSF YNFIYFILLI IVGSFFMINL CLVVIATQFS
410 420 430 440 450
ETKQREHRLM LEQRQRYLSS STVASYAEPG DCYEEIFQYV CHILRKAKRR
460 470 480 490 500
ALGLYQALQN RRQATGPGTP APAKPGPHSK ESSHCKLCPR HSSLDPTPHT
510 520 530 540 550
LVQPISAILA SDPSSCPRCQ HEAGRRPSGL GSMDSGQEGS GSGGSAEAEA
560 570 580 590 600
DGDGPQSSED GASSGLEKEE EQEDGAARLC GDVWRETRAK LRGIVDSKYF
610 620 630 640 650
NRGIMMAILV NTVSMGIEHH EQPEELTNIL EICNVVFTSM FALEMILKLA
660 670 680 690 700
AFGLFDYLRN PYNIFDSIIV IISIWEIVGQ ADGGLSVLRT FRLLRVLKLV
710 720 730 740 750
RFMPALRRQL VVLMKTMDNV ATFCMLLMLF IFIFSILGMH IFGCKFSLRT
760 770 780 790 800
DTGDTVPDRK NFDSLLWAIV TVFQILTQED WNVVLYNGMA STTPWASLYF
810 820 830 840 850
VALMTFGNYV LFNLLVAILV EGFQAEGDAN RSYSDEDQSS SNMEEFDKLP
860 870 880 890 900
EGLDNSGDLK LCPIPMTPNG HLDPGLPLGG HPGSTGAMGT APRLSLQPDP
910 920 930 940 950
VLVALDSRKS SVMSLGRISY DQRSLSSSRS SYYGPWGRSG TWASRRSSWN
960 970 980 990 1000
SLKHKPPSAE HESLLSGERG GSCVRACEGA REEAPTRTAP LHAPHAHHPH
1010 1020 1030 1040 1050
HGPHLAHRHR HHRRTLSLDT RDSVDLAELV PVVGAHSRTV WRAPGQAPGH
1060 1070 1080 1090 1100
EDCNGRMPNI AKDVFTKMDD RRDRGEDEEE IDYTLCFRVR KMIDVYKPDW
1110 1120 1130 1140 1150
CEVREDWSVY LFSPENKFRI LCQTIIAHKL FDYVVLAFIF LNCITIALER
1160 1170 1180 1190 1200
PQIEAGSTER IFLTVSNYIF TAIFVGEMTL KVVSLGLYFG EQAYLRSSWN
1210 1220 1230 1240 1250
VLDGFLVFVS IIDIVVSVAS AGGAKILGVL RVLRLLRTLR PLRVISRAPG
1260 1270 1280 1290 1300
LKLVVETLIS SLKPIGNIVL ICCAFFIIFG ILGVQLFKGK FYHCLGVDTR
1310 1320 1330 1340 1350
NITNRSDCVA ANYRWVHHKY NFDNLGQALM SLFVLASKDG WVNIMYNGLD
1360 1370 1380 1390 1400
AVAVDQQPVT NHNPWMLLYF ISFLLIVSFF VLNMFVGVVV ENFHKCRQHQ
1410 1420 1430 1440 1450
EAEEARRREE KRLRRLEKKR RKAQRLPYYA TYCPTRLLIH SMCTSHYLDI
1460 1470 1480 1490 1500
FITFIICLNV VTMSLEHYNQ PTSLETALKY CNYMFTTVFV LEAVLKLVAF
1510 1520 1530 1540 1550
GLRRFFKDRW NQLDLAIVLL SVMGITLEEI EINAALPINP TIIRIMRVLR
1560 1570 1580 1590 1600
IARVLKLLKM ATGMRALLDT VVQALPQVGN LGLLFMLLFF IYAALGVELF
1610 1620 1630 1640 1650
GKLVCNDENP CEGMSRHATF ENFGMAFLTL FQVSTGDNWN GIMKDTLRDC
1660 1670 1680 1690 1700
THDERSCLSS LQFVSPLYFV SFVLTAQFVL INVVVAVLMK HLDDSNKEAQ
1710 1720 1730 1740 1750
EDAEMDAEIE LEMAHGLGPV PGPGPGPGPC PCPGPRLPTS SPGAPSRGSG
1760 1770 1780 1790 1800
GAGVGGDNEG HLCRHCYSPA QETLWLDSVS LIIKDSLEGE LTIIDNLSGS
1810 1820 1830 1840 1850
IFHHYSSPAG CDKCHHDKQE VQLAETEAFS LNSDRSSSVL LGDDLSLEDP
1860 1870 1880 1890 1900
TACPQGPKES KGELEPPEPL QAGDLDECFF PFANAPVSAG PESLLCEMEA
1910 1920 1930 1940 1950
IPFNPVQSWL KHESSQAPPS PFSPDASSPL LQMPVEFFHP AVSASQKGQG
1960 1970 1980 1990 2000
PGMSAGALPK IALQGSWASL RSPSVNCTLL RQATVSDTSL DASPSSSAGS
2010 2020 2030 2040 2050
LQTTLEDSLT LSDSPRRGLG PPVQVPGPRA GLSPTTRRRL SLRGRGLFSL
2060 2070 2080 2090 2100
RGLRAHQRSH SSGGSTSPGC THHDSMDPSD EEGRGGTGGG GAGSEHSETL
2110 2120 2130 2140 2150
SSLSLTSLFC PPPTLPPPGL TPARKFSSTS SLAAGPGRPG ATVSAGGLAR
2160 2170 2180 2190
SPSWAADRSK DPPGQVQLAS GLGSSAPEPQ PPPGELESAD AASKRKR
Length:2,197
Mass (Da):242,412
Last modified:May 10, 2017 - v1
Checksum:iEFFB338FD4727327
GO

Sequence databases

RefSeqiXP_005067058.1. XM_005067001.1.

Genome annotation databases

GeneIDi101835044.

Similar proteinsi

Entry informationi

Entry nameiA0A1U7QGG9_MESAU
AccessioniPrimary (citable) accession number: A0A1U7QGG9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported