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Protein

Undecaprenyl-diphosphatase

Gene

uppP_1

Organism
Mycobacterium abscessus subsp. massiliense
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppP_1Imported
Synonyms:uppPUniRule annotation
ORF Names:SAMEA4008291_03245Imported
OrganismiMycobacterium abscessus subsp. massilienseImported
Taxonomic identifieri1962118 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium abscessus

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei97 – 120HelicalUniRule annotationAdd BLAST24
Transmembranei132 – 151HelicalUniRule annotationAdd BLAST20
Transmembranei203 – 224HelicalUniRule annotationAdd BLAST22
Transmembranei236 – 257HelicalUniRule annotationAdd BLAST22
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiView protein in InterPro
IPR003824. UppP.
PANTHERiPTHR30622. PTHR30622. 1 hit.
PfamiView protein in Pfam
PF02673. BacA. 1 hit.
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1U3U0Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNEGKNGMT LWEMFTAAVL GIVEGLTEYA PVSSTGHMII ADDIWLKSGS
60 70 80 90 100
LMNPEAANSF KVVIQLGSIL AVAIVFKDRI LHLLGLKKNV TRDQQKGYRL
110 120 130 140 150
TIAQIAVGLV PAAVLGFLFE DFIDRYLFSV RTVAYGLIAG AVLMLIADWI
160 170 180 190 200
NKRKETIDTV DRITYKQAFC VGLFQCLALW PGFSRSGSTI AGGVIVGLNH
210 220 230 240 250
RAAADFTFIM AIPIMAGASL LKLVKYWSSL SYDMIPFFLV GFICAFVVAL
260 270 280
LVVKFFLRLI NRIKLVPFAI YRVILGIILI MLVR
Length:284
Mass (Da):31,394
Last modified:May 10, 2017 - v1
Checksum:i21179C68918FF8D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FVSM01000013 Genomic DNA. Translation: SLC17716.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1U3U0Z5_9MYCO
AccessioniPrimary (citable) accession number: A0A1U3U0Z5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: September 27, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)