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Protein

D-alanine--D-alanine ligase

Gene

ddl_2

Organism
Mycobacterium abscessus subsp. abscessus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi293Magnesium or manganese 1UniRule annotation1
Metal bindingi306Magnesium or manganese 1UniRule annotation1
Metal bindingi306Magnesium or manganese 2UniRule annotation1
Metal bindingi308Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddl_2Imported
Synonyms:ddlUniRule annotation
ORF Names:SAMEA2275726_06011Imported
OrganismiMycobacterium abscessus subsp. abscessusImported
Taxonomic identifieri1185650 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium abscessus

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 339ATP-graspInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1U1F7A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKENICIVY GGKSAEHDVS ILTAQNVLNA INKDKYLVDI IYITNDGQWK
60 70 80 90 100
KKENITKNIK TVEELHLEDI SPGEITLLLK ENGEGSKYDA IFPLLHGPNG
110 120 130 140 150
EDGTIQGLFE VLDLPYVGNG VLAASSSMDK LVMKQLFEHR GLPQLPYISF
160 170 180 190 200
LRSEYEKYEG NIIKLVNDKL TYPVFVKPAN LGSSVGISKC NNEDELKKGI
210 220 230 240 250
EEAFQFDRKL VIEQGIIARE VEVAVLGNDY PETTWPGEVI KDVQFYDYKS
260 270 280 290 300
KYKDGKISLQ IPADLDEEVQ MTLRNMALEA FKATDCSGLV RADFFVTEDN
310 320 330 340 350
QIYINETNAM PGFTAFSMYP SLWENMGLSY SDLITKLIDL AKERYEDKKK

NKYTID
Length:356
Mass (Da):40,292
Last modified:May 10, 2017 - v1
Checksum:iD8E7F5DD04946EC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FVMP01000028 Genomic DNA Translation: SKU35966.1

Similar proteinsi

Entry informationi

Entry nameiA0A1U1F7A6_9MYCO
AccessioniPrimary (citable) accession number: A0A1U1F7A6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: November 22, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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