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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Clostridium sp. USBA 49
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
ORF Names:SAMN05428976_102399Imported
OrganismiClostridium sp. USBA 49Imported
Taxonomic identifieri1881060 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000190748 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei47 – 68HelicalUniRule annotationAdd BLAST22
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei112 – 131HelicalUniRule annotationAdd BLAST20
Transmembranei151 – 168HelicalUniRule annotationAdd BLAST18
Transmembranei175 – 193HelicalUniRule annotationAdd BLAST19
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 259HelicalUniRule annotationAdd BLAST29
Transmembranei298 – 320HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1T4WI76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKLVYSVLI AFFISLILGP IFIPILHRLK FGQNIREEGP KSHRKKAGTP
60 70 80 90 100
TMGGLIFIFS SFITMAILVR KPSDEAMVAL YAFIAFGIIG AIDDILKIIH
110 120 130 140 150
KKNLGLKSGQ KMILLIIVSA IFGYYASKNF IDGTVIIIPF FQKSIDLGKG
160 170 180 190 200
YIPFIILYYA ATTNAVNLTD GLDGLATSVT LLVMTFFALL SFGLGHYTLS
210 220 230 240 250
IFCGVVAGSL LGFLRYNAFP AQIFMGDTGS LALGGAIATV AMILKLPLLV
260 270 280 290 300
IIVGGIYVIE TFSVILQVAS FKLTGKRIFK MSPLHHHFEL SGWHETKIVS
310 320
VFSIITVILC LIAFLSLPAI K
Length:321
Mass (Da):35,053
Last modified:May 10, 2017 - v1
Checksum:i137C69373D2EE8A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FUYD01000002 Genomic DNA. Translation: SKA77020.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1T4WI76_9CLOT
AccessioniPrimary (citable) accession number: A0A1T4WI76
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: September 27, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported