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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

nbaC

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 2 Fe2+ ions per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU), Kynureninase (kynU)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (nbaC), 3-hydroxyanthranilate 3,4-dioxygenase (nbaC), 3-hydroxyanthranilate 3,4-dioxygenase (nbaC), 3-hydroxyanthranilate 3,4-dioxygenase (nbaC)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei47DioxygenUniRule annotation1
Metal bindingi51Iron 1; catalyticUniRule annotation1
Metal bindingi57Iron 1; catalyticUniRule annotation1
Binding sitei57SubstrateUniRule annotation1
Metal bindingi96Iron 1; catalyticUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Metal bindingi125Iron 2UniRule annotation1
Metal bindingi128Iron 2UniRule annotation1
Metal bindingi162Iron 2UniRule annotation1
Metal bindingi165Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenaseUniRule annotationImported, Oxidoreductase
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:nbaCUniRule annotation
ORF Names:BVG01_05355Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000191148 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO. 1 hit.
InterProiView protein in InterPro
IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin_sf.
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiView protein in Pfam
PF06052. 3-HAO. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1T3V967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTLQSFNL LKWIDENKEL LKPPVNNIVI WQDSEFIAMI LGGPNRRRDF
60 70 80 90 100
HVDPSDEFFY QIKGECYVEC ITEEGKREVV TVKEGDVFML PAMVPHSPHR
110 120 130 140 150
VANTYGLVIE RKRSQGELED FVWFCDECNH EMHRVRVQLS DIEKQVKEAI
160 170
HSFNSNKEIR ACKNCGHIMP EEVEEWKCE
Length:179
Mass (Da):21,042
Last modified:May 10, 2017 - v1
Checksum:iDC4EB1789B22428F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MTAU01000003 Genomic DNA. Translation: OPD59974.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1T3V967_BACAN
AccessioniPrimary (citable) accession number: A0A1T3V967
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: November 22, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported